Ectopic expression of TIM-3 in lung cancers: a potential independent prognostic factor for patients with NSCLC

American Journal of Clinical Pathology
Xuewei ZhuangChunhong Ma

Abstract

T-cell immunoglobulin- and mucin domain-3-containing molecule 3 (TIM-3) is a membrane protein expressed in various kinds of immune cells and plays a pivotal role in immune regulation. Recently, TIM-3 was reported to be expressed aberrantly in melanoma cells, contributing to the low adhesion ability of tumor cells and promoting the survival of melanoma cells. We investigated TIM-3 expression in non-small cell lung cancers (NSCLCs), and further analyzed whether the aberrant expression of TIM-3 is related to the prognosis for patients with lung cancer. Tumor tissue samples from 30 patients with NSCLC were involved. Results of immunohistochemical analysis showed that TIM-3 stained positive on tumor cells in 86.7% (26/30) patients with primary NSCLC. The TIM-3 expression in NSCLC tumor cells was correlated with histologic type and pathologic T classification of the disease (P < .05). More importantly, patients with TIM-3-positive tumor cells had a significantly shorter survival time than those with TIM-3-negative tumors. Multivariate analysis demonstrated the significant role of TIM-3 expression in tumor cells as an independent prognostic factor for patients with NSCLC (relative risk, 4.481; 95% confidence interval, 1.790-11.22; P =...Continue Reading

References

Aug 1, 1988·Journal of Surgical Oncology·K YasumotoK Nomoto
Jun 1, 1997·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S L Graziano
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·A ColasanteF B Aiello
Jul 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D J KwiatkowskiD J Sugarbaker
Aug 1, 1997·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·T MiyoshiY Monden
Jan 11, 2002·The New England Journal of Medicine·Desmond N Carney
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tsunekazu OikawaMiyuki Azuma
Oct 13, 2006·Chest·Julian R MolinaJames R Jett
Nov 11, 2006·The Journal of Investigative Dermatology·Zoltan WienerAndras Falus
Jul 11, 2007·Blood·Susumu NakaeStephen J Galli
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li YangDavid A Hafler
Apr 11, 2008·Journal of Human Genetics·Patrick BrückKlaus Badenhoop
Feb 20, 2009·Blood·Masafumi NakayamaKo Okumura
Aug 14, 2009·European Journal of Immunology·William D HastingsVijay K Kuchroo
Aug 29, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Xuewei ZhuangLining Zhang

❮ Previous
Next ❯

Citations

May 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Taiwu XiaoLei Gao
Sep 21, 2013·International Journal of Hematology·Yoshikane Kikushige, Toshihiro Miyamoto
Dec 25, 2012·Journal of Molecular Histology·Jingwei LiYongwen Chen
Jan 30, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jianwen BaiQinchuan Li
Sep 12, 2015·Acta Oncologica·Xiaodong LiChangping Wu
Feb 6, 2013·Cytokine & Growth Factor Reviews·Simone MocellinPierluigi Pilati
Oct 30, 2015·British Journal of Cancer·Qianqian ZhangLifen Gao
Jul 28, 2015·Human Vaccines & Immunotherapeutics·Lin Cheng, Zhihua Ruan
Jul 6, 2016·Frontiers in Immunology·Ranferi Ocaña-GuzmanIsabel Sada-Ovalle
Sep 15, 2016·Expert Review of Clinical Pharmacology·G SantabarbaraC Gridelli
Feb 27, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ross A SooByoung-Chul Cho
Mar 31, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y XuF Zheng
Jul 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Yong-Rui PiaoXiu-Zhe Dong
Oct 13, 2018·Journal of Hematology & Oncology·Feifei LiuZhi Chen
Nov 30, 2016·Frontiers in Oncology·Pranshu BansalYanis Boumber
May 31, 2018·Iranian Journal of Biotechnology·Vida HomayouniAbbas Rezaei
Jan 4, 2020·Indian Journal of Dermatology·Fereshteh Hosseini ValikiFarzad Motevalli Haghi
Oct 23, 2020·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Narges Zargar BalajamFarzad Kompani
Nov 1, 2020·Translational Oncology·Renpei KatoWataru Obara
Jun 8, 2021·Cancer Biomarkers : Section a of Disease Markers·Yuting CaoYigang Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.