Ectopic hormone-secreting pheochromocytoma: a francophone observational study.

World Journal of Surgery
James Kirkby-BottBruno Carnaille

Abstract

Ectopic hormone-secreting pheochromocytomas are rare; only case reports exist in the literature. This condition has been linked with increased malignancy, familial syndromes, and ACTH secretion. We wanted to test these hypotheses and shed light on the nature of ectopic hormone-secreting pheochromocytomas. This is a multicenter (francophone) observational study. Inclusion was based upon abnormal preoperative hormone tests in patients with pheochromocytoma that normalized after removal of the tumor. Where possible, immunohistochemistry was performed to confirm that ectopic secretion came from the tumor. Sixteen cases were found: nine female and seven male patients. Median age was 50.5 (range 31-89) years. Most presented with hypertension, diabetes, or cushingoid features. Ten patients had specific symptoms from the ectopic hormone secretion. Two had a familial syndrome. Of eight patients with excess cortisol secretion, three died as a result of the tumor resection: two had pheochromocytomas >15 cm and their associated cortisol hypersecretion complicated their postoperative course. The other died from a torn subhepatic vein. The 13 survivors did not develop any evidence of malignancy during follow-up (median 50 months). Symptoms f...Continue Reading

References

Aug 23, 1979·The New England Journal of Medicine·R F SparkL Landsberg
Aug 1, 1979·Annals of Internal Medicine·H Heath, A J Edis
Jan 1, 1992·Journal of Cardiovascular Pharmacology·P R Saxena
Jan 1, 1992·Archives of Surgery·M F HerreraS L Asa
Jan 1, 1991·Acta Haematologica·K SuzukiT Takemura
Jul 1, 1985·Southern Medical Journal·J W InterlandiJ N Sullivan
Nov 1, 1986·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·A KanamoriK Yamaguchi
Feb 1, 1985·The Journal of Urology·A M ShanbergM Perley
Nov 1, 1984·Acta Pathologica Japonica·K KakudoM Fukuchi
Dec 1, 1994·Journal of Endocrinological Investigation·M TerzoloA Angeli
Jan 1, 1997·Scandinavian Journal of Infectious Diseases·A SalahuddinJ Loewenstein
Sep 23, 1998·Surgery Today·M KawaiK Kawamura
Dec 2, 1998·Basic Research in Cardiology·A DendorferP Dominiak
Apr 27, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·K Kalavantavanich, C M Schramm
Sep 27, 2001·World Journal of Surgery·J P AniszewskiJ A van Heerden
Aug 3, 2002·European Journal of Endocrinology·P Sytze van DamWouter W de Herder
Mar 13, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Roman MuffJan A Fischer
Aug 9, 2003·Journal of Endocrinological Investigation·M MinettoA Angeli
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·P H EngD H Khoo
May 26, 2005·The Journal of Clinical Endocrinology and Metabolism·Ioannis IliasLynnette K Nieman
Oct 6, 2005·American Journal of Hypertension·Fumio OtsukaHirofumi Makino
Apr 18, 2006·Pharmacology & Therapeutics·Toshihiko IshimitsuHiroaki Matsuoka
Oct 14, 2006·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·F BayraktarA Comlekci
May 8, 2008·The Journal of Endocrinology·Ryo MorimotoKazuhiro Takahashi
Dec 3, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H TokudaO Kozawa
Jul 3, 2010·Journal of Molecular Neuroscience : MN·Kazuhiro TakahashiKazuhito Totsune

❮ Previous
Next ❯

Citations

May 3, 2013·Journal of the American Veterinary Medical Association·Ross N LarsonSusan W Grey
Jun 27, 2015·Endocrinology, Diabetes & Metabolism Case Reports·Annika SjoeholmBenjamin J Wheeler
Jul 29, 2018·Der Pathologe·W Saeger
Sep 7, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Federica ChialeSilvia Einaudi
Feb 17, 2017·Endocrinology, Diabetes & Metabolism Case Reports·Elise FlynnEgo Seeman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.