Ectopic pregnancy in a breast cancer patient receiving trastuzumab

Reproductive Toxicology
Paul BerveillerF Goldwasser

Abstract

Cervico-isthmic pregnancy is a rare form of ectopic pregnancy with a poor obstetrical prognosis, whose mechanism remains unclear. Preclinical data indicate that HER-2 plays a major role in embryo implantation. We report a case of cervico-isthmic pregnancy occurring during treatment with trastuzumab (Herceptin, a monoclonal antibody to HER-2). A 43-year-old woman presented with abnormal vaginal bleeding, while she was receiving trastuzumab for the last 14 months as an adjuvant therapy for a node-positive, HER-2 positive breast cancer. The diagnosis of evolutive cervico-isthmic pregnancy was confirmed by iterative ultrasonographic examinations. Given the poor obstetrical prognosis, the patient underwent voluntary abortion. The use of trastuzumab during pregnancy is still poorly documented, and its safety is not yet established. Given the importance of HER-2 in embryo implantation and fetal development, its putative role in this abnormal embryo implantation should be discussed.

References

Feb 3, 2005·DNA and Cell Biology·Jing NiSidong Xiong
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Citations

Oct 12, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Frédéric AmantAndreas Du Bois
Jul 25, 2009·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Nele Pentsuk, Jan Willem van der Laan
Aug 3, 2011·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Christine L MandrawaSusan P Walker
Sep 8, 2011·Journal of Surgical Oncology·Paul BerveillerOlivier Mir
Jul 27, 2011·Therapeutic Advances in Medical Oncology·Sophie E McGrath, Alistair Ring
Oct 29, 2010·Expert Review of Clinical Immunology·Hatem A AzimFedro A Peccatori
Jun 2, 2009·Nature Reviews. Clinical Oncology·Hatem A AzimAron Goldhirsch
Apr 24, 2009·Obstetrical & Gynecological Survey·Daniel M AveryDiane M Harper
Apr 28, 2021·BMC Cancer·Angeliki AndrikopoulouFlora Zagouri

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