Ectopic primary intrathyroidal thymoma: a clinicopathological and immunohistochemical analysis of 3 cases

Human Pathology
Annikka Weissferdt, Cesar A Moran

Abstract

Thymomas are rare tumors that occasionally arise from ectopic locations. Ectopic thymomas originating within the thyroid gland are an exceedingly uncommon clinical entity that has only been described sporadically. In this study, we present the clinicopathological and immunohistochemical features of 3 primary intrathyroidal thymomas. The patients were 2 women and 1 man between the ages of 43 and 53 years (average, 48 years). Clinically, the patients presented with neck pain or enlarged thyroid glands. Physical examination and thyroid ultrasound revealed the presence of nodular masses confined to the thyroid parenchyma. No concurrent mediastinal tumors were identified in any of the cases, and none of the patients had a history of thymoma. Fine needle aspirate performed in 1 case was interpreted as possibly Hashimoto thyroiditis. Surgical resection was performed in all cases. Grossly, the lesions were circumscribed masses measuring from 1 to 4 cm in size. Histologically, the lesions showed the classic biphasic cellular proliferation of thymomas characterized by varying proportions of epithelial cells and lymphocytes. Two patients remain alive and well 1.5 to 2 years after their surgical resection, whereas the third patient was los...Continue Reading

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Citations

Jun 4, 2016·Virchows Archiv : an International Journal of Pathology·Annikka Weissferdt, Cesar A Moran
Sep 17, 2016·Pathology, Research and Practice·Borislav A Alexiev, Anjana V Yeldandi
Nov 6, 2018·Journal of Clinical Pathology·Weijie LiDouglas Rivard
May 11, 2018·Endocrine Pathology·Zubair BalochSylvia L Asa

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