PMID: 7370641Mar 15, 1980Paper

Ectopic production of methionine enkephalin and beta-endorphin

British Medical Journal
P T PullanA Galvao-Teles

Abstract

Immunoreactive methionine enkephalin and beta-endorphin were sought by serial dilution of tissue extracts and assay of chromatographic fractions in non-endocrine tumour tissue from three patients with the ectopic adrenocorticotrophin syndrome associated with carcinoid tumours and in normal lung tissue and thymic tissue from a patient with myasthenia gravis. In all cases serial dilution of extracts showed parellelism to standard radioimmunoassay curves. The two peptides were found in high concentration in the three tumours but were undetectable in the control tissues. In a single case tested the methionine enkephalin concentration in a vein draining the tumour was twice that in a peripheral vein. In view of their profound effect on behaviour in animals and potent analgesic activity in animals and man the ectopic secretion of methionine enkephalin and beta-endorphin may modify the clinical features of a wide variety of tumours and produce some of the diverse clinical syndromes associated with malignancy.

References

Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H H LohC H Li
May 6, 1978·Lancet·S N SullivanJ M Polak
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Citations

Dec 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·C J Poole
Nov 1, 1987·European Journal of Pediatrics·E S McCaugheyL H Rees
Mar 1, 1983·Clinics in Endocrinology and Metabolism·A Grossman, V Clement-Jones
Jan 17, 1980·Nature·V Clement-JonesG M Besser
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·T Hedner, J Cassuto
Dec 3, 1987·The New England Journal of Medicine·D G BostwickK G Bensch
Jun 1, 1984·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·D S Goldbloom
Jan 1, 1982·Journal of Endocrinological Investigation·J BakerP T Pullan
Jan 1, 1986·Critical Reviews in Oncology/hematology·V P TerranovaR M Lyall

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