PMID: 6160287Aug 1, 1980Paper

Ectopic synthesis of pregnancy specific beta 1-glycoprotein (SP1) and placental specific tissue proteins (PP5, PP10, PP11, PP12) in nontrophoblastic malignant tumours. Possible markers in oncology

Klinische Wochenschrift
N InabaH Bohn

Abstract

By using an enzyme-bridge immunoperoxidase (PAP) technique, localization of so-called pregnancy-specific beta 1-glycoprotein (SP1) and placental-specific tissue proteins (PP5, PP10, PP11, PP12) was investigated in 19 cases of breast cancer, 24 cases of testicular malignant tumours, 12 cases of gastric cancer and some cases of other malignant tumours. These five glycoproteins isolated from human term placentae and characterized by Bohn are localised mainly in the cytoplasm, or nucleus of syncytiotrophoblast and appear to be specific for the trophoblast. But to a certain percentage these proteins could also be detected in the cytoplasma of malignant cells: In breast cancer, SP1 was present in 52.6% of cases, PP5 in 63.2%, PP10 in 68.4%, PP11 in 55.6% and PP12 in 31.6%. In testicular malignant tumours the detection rates of these proteins varied from 20.8 to 75.0% and in gastric cancer from 41.7 to 66.7%. In total 50% of the tumours tested were SP1-positive, 58.3% PP5-positive, 55.6% PP10-positive, 38.0% PP11-positive and 31.9% PP12-positive. In addition, it was found that mononuclear histiocytes showed a strong cytoplasmic staining for PP10 and PP12 and that a few other non-cancerous cells (i.e. striated cells in gastric metaplas...Continue Reading

References

Aug 1, 1979·American Journal of Obstetrics and Gynecology·S W RosenS A Aaronson
May 1, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·K HigashinoJ Sakurai
Jan 1, 1977·Journal of Clinical Pathology·C H HorneG D Milne
Oct 28, 1977·Archiv für Gynäkologie·H Bohn, W Winckler
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·B Mintz, K Illmensee
Sep 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T E MasonR B Dreskin
Jun 18, 1966·Nature·J B Gurdon, V Uehlinger

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Citations

Sep 1, 1991·Biulleten' eksperimental'noĭ biologii i meditsiny·K K PugachevK P Shabalov
Jan 1, 1988·Archives of Gynecology and Obstetrics·I FukazawaB Wiklund
Jan 1, 1989·Archives of Gynecology and Obstetrics·V BrieseR R Strache
Jan 1, 1985·Archives of Gynecology·A G Ahmed, A Klopper
Oct 22, 2008·The Journal of Biological Chemistry·Pietro LaneveElisa Caffarelli
Jul 22, 2014·Developmental and Comparative Immunology·Mariarosa PascalePatrizia Falabella
Mar 1, 1985·Placenta·A Klopper, A G Ahmed
Jan 1, 1983·Annals of the New York Academy of Sciences·M SeppäläH Bohn
Jun 10, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David Haig
Nov 21, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Per-Henrik D EdqvistFredrik Pontén
Sep 1, 1993·Asia-Oceania Journal of Obstetrics and Gynaecology·I MaekawaH Bohn

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