PMID: 11934649Apr 6, 2002Paper

ED-71, a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis

Bone
Yasushi UchiyamaEtsuro Ogata

Abstract

Although active vitamin D is used in certain countries for the treatment of osteoporosis, the risk of causing hypercalcemia/hypercalciuria means that there is only a narrow therapeutic window, and this has precluded worldwide approval. The results of our previous animal studies have suggested that the therapeutic effect of active vitamin D on bone loss after estrogen deficiency can be dissociated at least partly from its effect of enhancing intestinal calcium absorption and suppressing parathyroid hormone (PTH) secretion. To test this, we compared the effects of ED-71, a hydroxypropoxy derivative of 1alpha,25-dihydroxyvitamin D3, with orally administered alfacalcidol, on bone mineral density (BMD) and the bone remodeling process as a function of their effects on calcium metabolism and PTH, in a rat ovariectomy (ovx) model of osteoporosis. ED-71 increased bone mass at the lumbar vertebra to a greater extent than alfacalcidol, while enhancing calcium absorption (indicated by urinary calcium excretion) and decreasing serum PTH levels to the same degree as alfacalcidol. ED-71 lowered the biochemical and histological parameters of bone resorption more potently than alfacalcidol, while maintaining bone formation markers. These result...Continue Reading

References

Apr 13, 1989·The New England Journal of Medicine·H ReichelA W Norman
Nov 1, 1972·The Journal of Clinical Investigation·C A Frolik, H F DeLuca
Feb 2, 1995·The New England Journal of Medicine·S C Manolagas, R L Jilka
Jan 1, 1996·Calcified Tissue International·P RüegseggerR Müller
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·H YasudaT Suda
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisM N Beneton
Sep 15, 1999·Calcified Tissue International·A ShiraishiE Ogata

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Citations

May 19, 2009·Journal of Bone and Mineral Metabolism·Sadaoki SakaiYoshiaki Toyama
Oct 22, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Yoshiyuki Ono
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·L A FitzpatrickJ Barsony
Sep 5, 2006·Evidence-based Complementary and Alternative Medicine : ECAM·Saburo HidakaMasayoshi Yamaguchi
Jan 21, 2006·The Journal of Clinical Investigation·Hisashi TakasuKyoji Ikeda
Oct 9, 2013·Clinical Interventions in Aging·Yuko NoguchiRyoichi Takayanagi
Sep 10, 2011·Drugs·Mark Sanford, Paul L McCormack
Dec 24, 2011·Drugs & Aging·Mark Sanford, Paul L McCormack
May 13, 2014·BoneKEy Reports·Toshio MatsumotoFumiaki Takahashi
Dec 5, 2008·Nutrition Reviews·Hisashi Takasu
Mar 13, 2013·Expert Opinion on Pharmacotherapy·Hiroshi Hagino
Apr 19, 2013·Revista española de cirugía ortopédica y traumatología·M Mesa-RamosP Carpintero-Benítez
Nov 24, 2011·Archives of Biochemistry and Biophysics·Tatsuo SudaNaoyuki Takahashi
Mar 20, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Toshio MatsumotoNaoki Tsuji
Apr 20, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Suguru HaradaHitoshi Saito
Aug 18, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Takeshi KondoSohei Kitazawa
Sep 15, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hua Zhu KeThomas A Brown
Nov 5, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Suguru HaradaNaoyuki Takahashi
Oct 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hector F DeLucaLori Plum
Nov 22, 2013·Journal of Periodontal Research·S H SteinD A Tipton
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Masahiko SatoYanfei L Ma
Aug 17, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Naoaki MuraoYoshinori Aso
Jul 22, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sadaoki SakaiKoichi Endo
Jul 1, 2015·BMC Musculoskeletal Disorders·Yusuke YamasakiHiroshi Hagino
Apr 9, 2015·Canadian Journal of Physiology and Pharmacology·Hiroshi Hagino
Dec 12, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Naoyuki Takahashi
Oct 17, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Hitoshi SaitoNorio Amizuka
Mar 5, 2013·Bioorganic & Medicinal Chemistry·Hirotaka KashiwagiTadakatsu Takahashi

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