EDA mutation as a cause of hypohidrotic ectodermal dysplasia: a case report and review of the literature

Genetics and Molecular Research : GMR
S X HuangM L Ou

Abstract

Ectodermal dysplasia (ED) represents a collection of rare disorders that result from a failure of development of the tissues derived from the embryonic ectoderm. ED is often associated with hair, teeth, and skin abnormalities, which are serious conditions affecting the quality of life of the patient. To date, a large number of genes have been found to be associated with this syndrome. Here, we report a patient with hypohidrotic ED (HED) without family history. We identified that this patient's disorder arises from an X-linked HED with a mutation in the EDA gene (G299D) found by whole-exome sequencing. In addition, in this paper we summarize the disease-causing mutations based on current literature. Overall, recent clinical and genetic research involving patients with HED have uncovered a large number of pathogenic mutations in EDA, which might contribute to a full understanding of the function of EDA and the underlying mechanisms of HED caused by EDA mutations.

Citations

Mar 25, 2018·The Journal of Dermatology·Aoi OkuboTakuro Kanekura
Jun 2, 2018·International Journal of Dermatology·Julia Reyes-RealiGlustein Pozo-Molina
Jun 16, 2018·The Journal of Dermatology·Mami NakajimaRiichiro Abe
Jul 4, 2019·Ocular Immunology and Inflammation·Francisco Lucero SaáPablo Chiaradía
Jul 28, 2016·G3 : Genes - Genomes - Genetics·Dominik P WalukArnaud Galichet

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