Edaravone attenuates monocyte adhesion to endothelial cells induced by oxidized low-density lipoprotein

Biochemical and Biophysical Research Communications
Zhijuan LiLiping Wang

Abstract

Oxidized low-density lipoprotein (oxLDL) plays a vital role in recruitment of monocytes to endothelial cells, which is important during early stages of atherosclerosis development. Edaravone, a potent and novel scavenger of free radicals inhibiting hydroxyl radicals, has been clinically used to reduce the neuronal damage following ischemic stroke. In the present study, Edaravone was revealed to markedly reduce oxLDL-induced monocyte adhesion to human umbilical vein endothelial cells (HUVECs). The inhibitory mechanism of Edaravone was associated with suppression of the chemokine MCP-1 and adhesion molecule VCAM-1 and ICAM-1 expression. In addition, luciferase reporter assay results revealed that administration of Edaravone attenuated the increase in NF-κB transcriptional activity induced by oxLDL. Notably, it's also shown that Edaravone treatment blocked oxLDL induced p65 nuclear translocation in HUVECs. Results indicate that Edaravone negatively regulates endothelial inflammation.

References

May 30, 2009·Journal of cardiology·Epaminondas Zakynthinos, Nikolitsa Pappa
Dec 14, 2011·Hematology·Zane S Kaplan, Shaun P Jackson
Jan 1, 2008·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·Mitsuhiro YamamuraYuji Miyamoto
Jun 22, 2012·Histochemistry and Cell Biology·Nicolas SchlegelJens Waschke

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Citations

Apr 15, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lin YangGuangyu Qi

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