Edaravone for the treatment of amyotrophic lateral sclerosis

Expert Review of Neurotherapeutics
Hiide Yoshino

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive fatal disorder that affects all skeletal muscles, leading to death, mostly within 2-4 years from onset. To date, the anti-glutamatergic drug riluzole is the only drug that has been approved for the treatment of this disease; however, its efficacy is modest. Oxidative stress is considered to be involved in the pathology of ALS, and in this regard, the free radical scavenger edaravone, which was originally developed for the treatment of acute ischemic stroke, has also been developed for the treatment of ALS. Areas covered: This review describes the pharmacological properties of edaravone and the progress of clinical trials conducted to evaluate the efficacy of this drug in the treatment of ALS. Expert commentary: Edaravone is the first drug to show effective inhibition of the motor function deterioration experienced by ALS patients with early-stage probable and definite types. In order to effectively prolong the quality of motor function, edaravone treatment should be initiated as soon as the diagnosis has been confirmed; however, the respiratory function should be carefully monitored when a deterioration in breathing capacity is detected.

References

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Citations

May 31, 2019·International Journal of Molecular Sciences·Natalia NowickaJoanna Wojtkiewicz
Oct 23, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Zaynab ShakkourFiras Kobeissy
Nov 26, 2020·Cellular and Molecular Neurobiology·Zhenzhen XuRenshi Xu
Sep 18, 2020·Immunology·Falguni BaidyaPallab Bhattacharya
Dec 18, 2020·Frontiers in Cellular Neuroscience·Luke McAlaryNeil R Cashman
Oct 5, 2021·EMBO Molecular Medicine·Antonietta TaralloGiancarlo Parenti
Jan 11, 2022·JAMA Neurology·Simon WitzelUNKNOWN German Motor Neuron Disease Network (MND-NET)

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