EDB Fibronectin-Specific SPECT Probe 99m Tc-HYNIC-ZD2 for Breast Cancer Detection

ACS Omega
Xiao-Xuan YeMu-Sheng Zeng

Abstract

Extradomain-B fibronectin (EDB-FN), an oncofetal isoform of FN, is a promising diagnostic and therapeutic target of tumors, including breast cancer. Many EDB-FN-targeted drugs have been developed and have shown therapeutic effects in clinical trials. Molecular imaging to visualize EDB-FN-positive cancers may help select the right patients who will be benefit from EDB-FN-targeted therapy. Although a few EDB-FN-targeted imaging probes have been developed, the complicated manufacturing procedure and expensive material and equipment required limit their application for large-scale screening of EDB-FN-positive cancer patients. Thus, more simple and economic EDB-FN-targeted imaging probes are still urgently needed. Previously, we have identified a breast cancer-targeted peptide, CTVRTSADC. Coincidently, it was later identified as an EDB-FN-targeted peptide and named ZD2. In this study, we found a positive correlation between the binding activity of the ZD2 phage and the expression level of EDB-FN in breast cancer cells. Moreover, we observed the colocalization of the ZD2 peptide with EDB-FN in breast cancer cells. Furthermore, in vivo tumor targeting of the ZD2 phage, near-infrared fluorescence imaging, and flow cytometry showed tumo...Continue Reading

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Citations

Aug 1, 2019·Current Pharmaceutical Biotechnology·Hasanain Gomhor J AlqaraghuliRonak Rafipour
May 10, 2020·Molecular Oncology·Relinde I Y LieverseLudwig J Dubois
Jan 15, 2021·Chemistry, an Asian Journal·Adukkadan N RamyaKaustabh K Maiti
May 18, 2021·Journal of Inorganic and Organometallic Polymers and Materials·Pierre D Harvey, Jessica Plé

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Methods Mentioned

BETA
imaging techniques
phage-display
enzyme-linked immunosorbent assay
flow cytometry
ELISA
xenografts

Software Mentioned

Living Image
SPSS
FluoView
SPSS Statistics

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