Edetate Disodium-Based Treatment for Secondary Prevention in Post-Myocardial Infarction Patients

Current Cardiology Reports
Gervasio A Lamas, Omar M Issa

Abstract

An abundance of data, known for decades, is available linking metals, such as lead and cadmium, with cardiovascular disease. However, the idea that these toxic metals could be a modifiable risk factor for atherosclerosis did not become apparent clinically until the completion of the Trial to Assess Chelation Therapy in 2012. This pivotal study was the first double-blind, randomized, controlled trial of its kind to demonstrate a clear improvement in cardiovascular outcomes with edetate disodium therapy in a secondary prevention, post-myocardial infarction population. This effect size was most striking in diabetic patients, where the efficacy of edetate disodium was comparable, if not superior, to that of current guideline-based therapies. Given the economic burden of diabetes and cardiovascular disease, the potential impact of this therapy could be enormous if the results of this study are replicated.

References

Mar 1, 1992·Journal of Internal Medicine·B GuldagerS Ottesen
Sep 1, 1988·Medical Hypotheses·E Olszewer, J P Carter
Jan 1, 1995·Methods in Enzymology·H F Gilbert
Feb 1, 1995·Free Radical Biology & Medicine·S J Stohs, D Bagchi
Apr 1, 1996·The Journal of Cardiovascular Nursing·L T Chappell, M Janson
Feb 2, 2002·JAMA : the Journal of the American Medical Association·Merril L KnudtsonUNKNOWN Program to Assess Alternative Treatment Strategies to Achieve Cardiac Health (PATCH) Investigators
Nov 20, 2002·Archives of Internal Medicine·Mark Lustberg, Ellen Silbergeld
Jan 28, 2003·Diabetes Care·Gary G SchwartzAnastasia Ivanova
Feb 12, 1955·Journal of the American Medical Association·H I RUSSEKV J DORSET
Dec 1, 1956·The American Journal of the Medical Sciences·C N CLARKER E MOSHER
Jun 9, 2004·Circulation·Ana Navas-AcienEliseo Guallar
Aug 3, 2006·Environmental Health Perspectives·Wan-Fen LiHung-Yi Chuang
Sep 27, 2006·Circulation·Tim S Nawrot, Jan A Staessen
Jun 10, 2008·The New England Journal of Medicine·UNKNOWN Action to Control Cardiovascular Risk in Diabetes Study GroupWilliam T Friedewald
Mar 4, 2011·The New England Journal of Medicine·Hertzel C GersteinWilliam T Friedewald
Mar 29, 2011·Biochimica Et Biophysica Acta·Sho-ichi YamagishiSeiya Okuda
Nov 1, 2011·Free Radical Biology & Medicine·Gabriella LeonarduzziGiuseppe Poli
Dec 17, 2011·American Heart Journal·Gervasio A LamasKerry L Lee
Apr 5, 2012·Environmental Health Perspectives·Maria Tellez-PlazaEliseo Guallar
Mar 28, 2013·JAMA : the Journal of the American Medical Association·Gervasio A LamasUNKNOWN TACT Investigators
May 22, 2013·TheScientificWorldJournal·Margaret E Sears
Jun 26, 2013·Future Medicinal Chemistry·Norma Frizzell, John W Baynes
Aug 21, 2013·Current Atherosclerosis Reports·Maria Tellez-PlazaAna Navas-Acien
Sep 10, 2013·Trends in Endocrinology and Metabolism : TEM·Michaele B ManigrassoAnn Marie Schmidt
Feb 4, 2014·Annals of Internal Medicine·Gervasio A LamasUNKNOWN TACT (Trial to Assess Chelation Therapy) Investigators

❮ Previous
Next ❯

Citations

Mar 1, 2019·International Journal of Molecular Sciences·Alessandro Fulgenzi, Maria Elena Ferrero

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

© 2022 Meta ULC. All rights reserved