Edible Bird's Nest attenuates high fat diet-induced oxidative stress and inflammation via regulation of hepatic antioxidant and inflammatory genes

BMC Complementary and Alternative Medicine
Zhang YidaNorharina Ismail

Abstract

Edible Bird's nest (EBN) is an antioxidant-rich supplement that is popular in many parts of Asia. Its antioxidant and anti-inflammatory properties have been reported using in vitro system. This paper aimed to determine the antioxidant and anti-inflammatory effects of EBN in in high fat diet induced rats model. We evaluate if those properties can be translated in rats. High fat diet (HFD) was fed to rats for 12 weeks to determine its effects on oxidative stress and inflammation, and compared with HFD + Simvastatin and HFD + EBN (2.5 or 20 %). Weights were measured weekly, while serum and hepatic markers of oxidative stress (total antioxidant status and TBARS) and inflammation (interleukin 6 [IL-6], C-reactive protein [CRP] and tumor necrosis factor alpha [TNF-α]) were determined at the end of the intervention. In addition, transcriptional changes in hepatic antioxidant (superoxide dismutase, glutathione reductase, glutathione peroxidase) and inflammation (C-reactive protein, chemokine [C-C] motif 2, nuclear factor kappa beta 1 and tumor necrosis factor alpha) genes were evaluated. The results showed increases in oxidative stress (raised TBARS and lowered total antioxidant status) and inflammatory markers (raised CRP, IL-6 and TN...Continue Reading

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Citations

Nov 18, 2016·Journal of Integrative Medicine·Lee Suan Chua, Siti Najihah Zukefli
Apr 10, 2021·Frontiers in Pharmacology·Bee-Hui YeoOi-Ming Lai
May 13, 2018·Journal of Agricultural and Food Chemistry·Zack C F WongKarl W K Tsim
Oct 1, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Kunio KawanishiPhilip L S M Gordts

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