Editorial: Can dysregulated myelination be linked to ADHD pathogenesis and persistence?

Journal of Child Psychology and Psychiatry, and Allied Disciplines
Klaus-Peter Lesch

Abstract

Converging evidence from new epidemiologic, genetic, epigenetic, neuroimaging, and experimental model findings are further refining a long-standing concept, regarding the underlying neurobiology of attention-deficit/hyperactivity disorder (ADHD): that ADHD onset and its persistence into adulthood are the result of dysregulated myelination and associated alterations in neuronal plasticity - linked to disrupted brain maturation and the persistence of cognitive and emotional impairments across the life span. If supported by further work, this concept represents a pathophysiologic mechanism amenable to therapeutic intervention.

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Citations

Apr 8, 2020·BioResearch Open Access·Walter H MoosXiaohong Chen
Sep 15, 2021·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Patricia L EastSheila Gahagan

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