Editorial: Immune monitoring in solid organ transplantation

Clinical Biochemistry
Maria Shipkova, Eberhard Wieland

Abstract

Solid organ transplantation is inevitably associated with the activation of the immune system of the graft recipient. An advanced knowledge of the immunological mechanisms leading to acute and chronic rejection, the advent of powerful immunosuppressive drugs, and refined surgical techniques have made solid organ transplantation a standard therapy to replace irretrievable loss of vital functions. The immune system is a complex network involving immune cells, cytokines, chemokines, antibodies, and the complement system. Monitoring and ideally influencing the allo-response of the organ recipient against the donor antigens may help to personalize the immunosuppressive therapy including the disclosure of those patients who are suitable for weaning or even discontinuation of immunosuppression. Immune monitoring comprises as plethora of candidate biomarkers capable of reflecting the donor specific and non-donor specific net activation state of the immune system in transplant recipients both before and after initiation of the immunosuppressive therapy. This special issue of Clinical Biochemistry on Immune Monitoring addresses the basic effects of immune activation in solid organ transplantation and critically reviews candidate biomarke...Continue Reading

References

Apr 16, 2002·Clinical Therapeutics·Barry D KahanAtholl Johnston
Apr 27, 2010·Therapeutic Drug Monitoring·Gary A Levy
Jun 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E F ReedD Gjertson
Jun 28, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K S KeslarR L Fairchild
Jan 17, 2015·Transplantation·Edward K GeisslerAnita S Chong
Sep 30, 2015·Therapeutic Drug Monitoring·Maria ShipkovaEberhard Wieland

❮ Previous
Next ❯

Citations

Sep 30, 2016·Expert Review of Molecular Diagnostics·Michael NasrMinnie Sarwal
Mar 1, 2019·Therapeutic Drug Monitoring·Millán OlgaBrunet Mercè
May 3, 2019·Therapeutic Drug Monitoring·Mercè BrunetStein Bergan
Mar 19, 2019·Therapeutic Drug Monitoring·Olga MillánMercè Brunet
Jun 28, 2019·Frontiers in Immunology·El-Ad David AmirAdeeb H Rahman
Apr 4, 2019·Molecular Diagnosis & Therapy·Sanjeeva HerathZoltán H Endre
Dec 13, 2016·Clinical Biochemistry·Peter A Kavsak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Kidney International. Supplement
Niloufar SafiniaR I Lechler
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Paulo Ney Aguiar Martins
Expert Review of Clinical Immunology
Fadi IssaKathryn J Wood
Transplantation
Paulo Ney Aguiar MartinsStefan G Tullius
© 2022 Meta ULC. All rights reserved