Editorial: Itching to Know: Role of Fibrates in PBC

The American Journal of Gastroenterology
Cynthia Levy, Keith Lindor

Abstract

Approximately one-third of patients with primary biliary cholangitis (PBC) fail to respond to ursodeoxycholic acid (UDCA) and are at risk for progression to biliary cirrhosis and end-stage liver disease. In this paper by Pares et al., the authors evaluate the effect of long-term use of bezafibrate in patients with primary biliary cholangitis (PBC) and inadequate response to UDCA. They found that addition of bezafibrate led to normalization of serum alkaline phosphatase in half of the study subjects and major improvement in pruritus. Here we discuss these findings and place them in context with current knowledge about fibrates in PBC.

References

Jun 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keith D LindorUNKNOWN American Association for Study of Liver Diseases
Nov 6, 2010·Diabetologia·T M E DavisUNKNOWN Fenofibrate Intervention and Event Lowering in Diabetes Study investigators
Apr 18, 2015·Clinics and Research in Hepatology and Gastroenterology·Alla Y GrigorianCynthia Levy
Dec 3, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sumeyye SamurJagpreet Chhatwal
Apr 22, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver

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