Editor's Choice - Metformin Prescription is Associated with a Reduction in the Combined Incidence of Surgical Repair and Rupture Related Mortality in Patients with Abdominal Aortic Aneurysm

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
Jonathan GolledgeJ Moxon

Abstract

Currently there is no drug therapy for abdominal aortic aneurysm (AAA) and most previous investigations have focused on imaging rather than clinical outcomes. The aim of this study was to assess whether AAA related clinical events were lower in patients prescribed metformin. This was a prospective cohort observational study performed in three cities in Australia, which was designed to study risk factors for clinical events not simply to focus on metformin. Patients with an asymptomatic unrepaired AAA of any diameter ≥30 mm were recruited from hospital outpatient clinics and surveillance programs run at four centres. The main outcome was the requirement for AAA repair or AAA related mortality (AAA events). The association between metformin prescription and AAA events was assessed using Kaplan-Meier analysis and Cox proportional hazard analysis. Patients (1,080) with a mean (SD) initial AAA diameter of 46.1 (11.3) mm were followed for a mean (SD) of 2.5 (3.1) years until an AAA event (n = 454), death (n = 176), loss to follow up (n = 128), or completion of current follow up (n = 322). Patients with diabetes who were prescribed metformin (adjusted HR 0.63, 95% CI 0.44-0.93), but not patients with diabetes who were not prescribed m...Continue Reading

Citations

Jul 7, 2019·Journal of Internal Medicine·J GolledgeA Wanhainen
Feb 23, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Bo LiuZamaneh Kassiri
Apr 11, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·S Scott SuttonJames W Hardin
Aug 29, 2020·VASA. Zeitschrift für Gefässkrankheiten·Sigrid NikolChristine Espinola-Klein
Dec 19, 2019·European Heart Journal·Hans-Henning Eckstein, Lars Maegdefessel
Nov 18, 2018·Nature Reviews. Cardiology·Jonathan Golledge
Apr 8, 2021·Annals of Vascular Surgery·Agnieszka TurowiczMariusz Chabowski
Apr 17, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Jorn P MeekelKak K Yeung
Dec 24, 2020·Nature Reviews. Cardiology·Eduardo Bossone, Kim A Eagle
May 16, 2021·Journal of Cardiovascular Pharmacology·Bitao XiangKai Zhu
Nov 16, 2019·Journal of Vascular Surgery·Juliette RaffortFabien Lareyre

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