EDR is a stress-related survival factor from stroma and other tissues acting on early haematopoietic progenitors (E-Mix)

Cytokine
Peter DörmerWinfried Möller

Abstract

The erythroid differentiation regulator (EDR) is a highly conserved autocrine factor produced in many tissues. Its haemoglobin synthesis-inducing activity for human and murine erythroleukaemia cell lines had been detected in WEHI-3 conditioned medium. EDR functions were analysed in detail. It is released from cells immediately in response to various stressful conditions and enhances cell survival particularly at a lower concentration range and low cell density. At high cell density and high EDR concentration the opposite effect of an increase in cell death was observed. Its essential function within a tissue is considered to be the maintenance of growth homeostasis. Cells kept in culture for weeks show a decreasing responsiveness to EDR supply. This was also noted in freshly cloned EDR-responsive mouse erythroleukaemia cells pointing to a molecular adaptation process. Human haematopoietic progenitors were amplified 7-fold by EDR when kept at low cytokine levels. At saturating levels progenitors giving rise to at least two lineages in semisolid medium (E-mix) respond to EDR with an average 1.87-fold increase in colony numbers and a bell-shaped dose-response curve. Of the more mature BFU-E compartment a response was observed part...Continue Reading

References

Jan 15, 1979·International Journal of Cancer. Journal International Du Cancer·L Montagnier, J Gruest
Jan 1, 1989·Growth Factors·R M Böhmer, A W Burgess
Jul 1, 1989·British Journal of Haematology·I A ReillyN H Russell
Jun 1, 1994·Critical Reviews in Oncology/hematology·C VerfaillieJ B McCarthy
Sep 30, 1993·International Journal of Cancer. Journal International Du Cancer·M H FalkG W Bornkamm
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Koji YamamotoHidehiko Saito
Jan 31, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laetitia DevyJean-Michel Foidart
Oct 3, 2003·Trends in Cardiovascular Medicine·Andrew L LaslettMartin F Pera

❮ Previous
Next ❯

Citations

Feb 24, 2016·International Journal of Molecular Sciences·Kyung Eun KimDaeho Cho
Jun 24, 2011·The Journal of Investigative Dermatology·Min Kyung JungDaeho Cho
Oct 31, 2013·International Journal of Dermatology·Young Bok LeeHyun Jeong Park
Jul 5, 2005·Biochemical and Biophysical Research Communications·Alan R BrownJohn K Fazakerley
Dec 13, 2016·International Journal of Molecular Sciences·Youn Kyung HouhDaeho Cho
May 2, 2017·The Journal of Investigative Dermatology·Kyung Eun KimDaeho Cho
Mar 16, 2018·Gut Microbes·Allison M WeisJune L Round
Nov 4, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jeong Ho LeeYoung Soo Ahn
Oct 15, 2011·Experimental Dermatology·Hee Jung KimDae Ho Cho
Feb 23, 2020·Nature Communications·Todd BradleyBarton F Haynes
Nov 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne M VerhagenDouglas J Hilton
May 11, 2017·Proceedings of the National Academy of Sciences of the United States of America·Raymond SotoJune L Round
Dec 19, 2020·International Journal of Molecular Sciences·Myun Soo KimDaeho Cho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis