EDTA Chelation Therapy for the Treatment of Neurotoxicity

International Journal of Molecular Sciences
Alessandro Fulgenzi, Maria Elena Ferrero

Abstract

Neurotoxicity can be caused by numerous direct agents, of which toxic metals, organophosphorus pesticides, air pollution, radiation and electromagnetic fields, neurotoxins, chemotherapeutic and anesthetic drugs, and pathogens are the most important. Other indirect causes of neurotoxicity are cytokine and/or reactive oxygen species production and adoptive immunotherapy. The development of neurodegenerative diseases has been associated with neurotoxicity. Which arms are useful to prevent or eliminate neurotoxicity? The chelating agent calcium disodium ethylenediaminetetraacetic acid (EDTA)-previously used to treat cardiovascular diseases-is known to be useful for the treatment of neurodegenerative diseases. This review describes how EDTA functions as a therapeutic agent for these diseases. Some case studies are reported to confirm our findings.

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Citations

Nov 7, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Yu-Chen YangHui-Lin Wan
Aug 23, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Yu-Chen YangZhao-Hui Zhou
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Aug 7, 2020·Biomedicines·Alessandro FulgenziMaria Elena Ferrero
Jun 29, 2021·Journal of Mass Spectrometry : JMS·Sebastian Beck
Oct 15, 2021·Journal of Biomolecular Structure & Dynamics·Essam S A E H KhattabAhmed A Elhenawy

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