Education as Proxy for Cognitive Reserve in a Large Elderly Memory Clinic: 'Window of Benefit'.

Journal of Alzheimer's Disease : JAD
Salka S StaekenborgJules J Claus

Abstract

The role of cognitive reserve (CR) to explain individual differences in cognitive functioning is unclear in memory clinic patients. To examine the cross-sectional effect of CR on cognition in relation to levels of neurodegeneration in a large elderly single-center memory clinic population. We included patients with subjective cognitive impairment (SCI, n = 481), mild cognitive impairment (MCI, n = 628) or Alzheimer's disease (AD, n = 1,099). Education was used as proxy for CR and visually rated medial temporal lobe atrophy (MTA) on CT was used as parameter of neurodegeneration. Relations between CR, cognition, and MTA were analyzed with multiple linear regression adjusted for age, sex, and cerebral atrophy. In addition, we examined if education affects the relation between MTA and cognition using an interaction variable. Education was significantly related to all measures of cognition including subtests with an explained variance of education as a determinant of cognition of 11%. More highly educated patients had more advanced levels of MTA at the same level of cognition. All these results were stronger or only present in demented compared to non-demented patients but appeared no longer significant in those with lowest overall ...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
May 19, 2006·Neuroepidemiology·Francisco Caamaño-IsornaBahi Takkouche
Jan 17, 2012·Neuroradiology·Yawu LiuUNKNOWN AddNeuroMed Consortium
Oct 20, 2012·Lancet Neurology·Yaakov Stern
Mar 15, 2013·Neurology·Michael EwersUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Apr 18, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Silvia MorbelliFlavio Nobili
Jan 13, 2016·Journal of Alzheimer's Disease : JAD·Jules J ClausPhilip Scheltens
Mar 24, 2017·Brain : a Journal of Neurology·Sarah GregoryGeraint Rees
Jun 4, 2017·Neurobiology of Aging·Merle Christine HoenigAlexander Drzezga
Jan 11, 2019·Current Neurology and Neuroscience Reports·Corinne Pettigrew, Anja Soldan
Feb 8, 2019·Neurology·Robert S WilsonDavid A Bennett
Jul 4, 2019·Neurology·Anna Catharina van LoenhoudUNKNOWN Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.