Educational attainment and the heritability of self-reported hypertension among male Vietnam-era twins.

Psychosomatic Medicine
Jeanne M McCafferyRaymond Niaura

Abstract

To investigate the potential for gene x environment interaction in hypertension by examining the extent to which educational attainment modifies the heritability of hypertension in male twins. Prior twin and family studies have established that hypertension runs in families and is heritable. In addition, epidemiological research indicates that the prevalence of hypertension differs by socioeconomic factors, such as educational attainment. Twin structural equation modeling was used to examine educational attainment as a moderator of heritability of hypertension. Participants were 4301 monozygotic and 3414 dizygotic male Vietnam-era twins who provided data on both education (in years) and self-report of physician diagnosis of hypertension or medication usage. Heritability was 17 points lower among co-twins concordant for educational attainment of < or =14 years (0.46, 95% CI = 0.32-0.57) relative to co-twins concordant for >14 years of education (0.63, 95% CI = 0.54-0.71). The significant moderation of the heritability (p = .04) was confirmed in twin models examining educational attainment as a continuous moderator of hypertension. These results demonstrate that the expression of genetic vulnerability to hypertension can vary as ...Continue Reading

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Citations

Nov 5, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ting WuYonghua Hu
Dec 12, 2012·European Journal of Public Health·Angelique P A VermeirenMaurice P Zeegers
Jul 13, 2011·Pediatrics·Christina N Lessov-SchlaggarMelbourne F Hovell
Jul 13, 2011·Behavior Genetics·Sophie van der SluisConor V Dolan
Dec 7, 2011·Australasian Journal on Ageing·Perminder S SachdevUNKNOWN OATS research team

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