Educational delay and attainment in persons with neurofibromatosis 1 in Denmark

European Journal of Human Genetics : EJHG
Karoline DoserSusanne Oksbjerg Dalton

Abstract

Most research on psychosocial consequences of neurofibromatosis type 1 (NF1) has focused on the relationship between disease factors and cognitive functioning. NF1 may impair domains of learning and attention, resulting in low academic performance. This study is the first nationwide population-based cohort study to investigate educational attainment and delay in completing mandatory school by persons with NF1. Educational information was collected from 550 persons at the age of 30 (born 1965-1984). They were diagnosed with NF1 in Denmark and compared to a cohort of NF1-free persons matched on gender and age (n = 4295). Multinomial logistic models were applied to estimate odds ratios (ORs) for obtaining short (≤9 years) or medium (10-12 years) education compared to long education (>12 years) by the age of 30 years. We calculated the probability of graduating 9th year of mandatory school at different ages in 932 persons with NF1 and 7962 NF1-free persons (born 1965-2000) using quantile regression. The OR of educational completion for short- and medium-term education was three fold (95% CI 2.55-3.99) and 1.29 fold (95% CI 0.99-1.69) higher, respectively, for persons with NF1 than NF1-free persons after adjusting for birth year, ge...Continue Reading

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Citations

Jun 3, 2020·American Journal of Medical Genetics. Part a·Karoline DoserPernille Envold Bidstrup
May 20, 2020·European Journal of Human Genetics : EJHG·Trille Kristina KjaerSusanne Oksbjerg Dalton
Jul 10, 2020·Neuro-oncology Advances·Geohana Hamoy-JimenezCarolina Barnett
Dec 29, 2020·Clinical Genetics·Edvard JohanssonSirkku Peltonen
Jan 27, 2021·Journal of Medical Genetics·Line KenborgJeanette F Winther
Jul 15, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Roope A KallionpääJuha Peltonen
Jul 31, 2021·American Journal of Medical Genetics. Part a·Line KenborgJeanette F Winther

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