EEG asymmetry in borderline personality disorder and depression following rejection

Personality Disorders
Joseph E BeeneyMichael N Hallquist

Abstract

Borderline personality disorder (BPD) and major depressive disorder (MDD) share numerous features, including dysphoric affect, irritability, suicidality, and a heightened sensitivity to perceived interpersonal rejection. However, these disorders are associated with divergent profiles of reactivity to rejection: Individuals with MDD are more likely to respond with withdrawal and isolation, and those with BPD appear to respond with increased approach behaviors and greater hostility. Potential mechanisms underlying these divergent patterns of response have not been elaborated. The goal of the present study was to assess whether prefrontal cortical asymmetry is associated with these behavioral profiles. EEG alpha activity was recorded at baseline and after individuals with BPD, MDD and healthy controls (HCs) participated in a rejection task. Although no differences were found at baseline, results demonstrated that following rejection, individuals with BPD showed greater left cortical activation, consistent with approach motivation, whereas those with MDD showed greater right cortical activation, consistent with withdrawal motivation. HCs evidenced a more balanced cortical profile, as hypothesized. Although BPD and MDD are highly co...Continue Reading

Citations

Dec 2, 2015·Journal of Affective Disorders·Justin D Caouette, Amanda E Guyer
Oct 16, 2015·Current Opinion in Psychology·John J B Allen, Samantha J Reznik
Aug 11, 2016·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Sabrina B de FreitasGisele P Dias
Mar 16, 2018·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Stoyan PopkirovMartin Brüne
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Oct 6, 2019·European Archives of Psychiatry and Clinical Neuroscience·Matthias A ReinhardFrank Padberg
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May 23, 2017·Clinical Psychological Science : a Journal of the Association for Psychological Science·Johanna HeppTimothy J Trull
Oct 5, 2017·Borderline Personality Disorder and Emotion Dysregulation·Vera FlasbeckMartin Brüne

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