EEG Characteristics of Dementia With Lewy Bodies, Alzheimer's Disease and Mixed Pathology

Frontiers in Aging Neuroscience
Jessica J van der ZandeAfina W Lemstra

Abstract

Introduction: Previous studies on electroencephalography (EEG) to discriminate between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) have been promising. These studies did not consider the pathological overlap of the two diseases. DLB-patients with concomitant AD pathology (DLB/AD+) have a more severe disease manifestation. The EEG may also be influenced by a synergistic effect of the two pathologies. We aimed to compare EEG characteristics between DLB/AD+, "pure" DLB (DLB/AD-) and AD. Methods: We selected probable DLB patients who had an EEG and cerebrospinal fluid (CSF) available, from the Amsterdam Dementia Cohort (ADC). Concomitant AD-pathology was defined as a CSF tau/Aβ-42 ratio > 0.52. Forty-one DLB/AD+ cases were matched for age (mean 70 (range 53-85)) and sex (85% male) 1:1 to DLB/AD- and AD-patients. EEGs were assessed visually, with Fast Fourier Transform (FFT), network- and connectivity measures. Results: EEG visual severity score (range 1-5) did not differ between DLB/AD- and DLB/AD+ (2.7 in both groups) and was higher compared to AD (1.9, p < 0.01). Both DLB groups had a lower peak frequency (7.0 Hz and 6.9 Hz in DLB vs. 8.2 in AD, p < 0.05), more slow-wave activity and more prominent disruptions of...Continue Reading

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Citations

Jul 17, 2019·Clinical Medicine : Journal of the Royal College of Physicians of London·Olugbenro Akintade, Floyd Pierres
Oct 12, 2019·Alzheimer's Research & Therapy·Inger van SteenovenAfina W Lemstra
Jan 5, 2020·Expert Opinion on Pharmacotherapy·Benjamin Cretin, Frederic Blanc
Jul 9, 2020·Neurology·Jessica Joanne van der ZandeAfina Willemina Lemstra
Jun 5, 2020·Alzheimer's Research & Therapy·Casper T BrielsAlida A Gouw
Dec 14, 2019·Neurology and Therapy·Una Smailovic, Vesna Jelic
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Feb 12, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Alberto Jaramillo-JimenezDag Aarsland
Dec 15, 2020·Drugs & Aging·Benjamin Cretin
Jun 2, 2020·Parkinsonism & Related Disorders·Federico MassaFlavio Nobili
Apr 10, 2021·Annals of Clinical and Translational Neurology·Casper T BrielsAlida A Gouw

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Methods Mentioned

BETA
ELISAs

Software Mentioned

BrainWave
MATLAB
SPSS

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