EEG correlates of seizure freedom in genetic generalized epilepsies

Neurology. Clinical Practice
Udaya SeneviratneWendyl D'Souza

Abstract

We investigated the association between epileptiform EEG abnormalities and the preceding duration of seizure freedom in genetic generalized epilepsies (GGE). We analyzed 24-hour ambulatory EEG recordings of patients with GGE diagnosed and classified according to the International League Against Epilepsy criteria. We quantified epileptiform EEG abnormalities into density scores (total duration of epileptiform discharges per hour) and estimated the preceding seizure-free duration at the time of EEG recording based on the last self-reported seizure. We then employed regression analysis to quantitate the relationship between the duration of seizure freedom and EEG variables. We analyzed 6,923 epileptiform discharges from 105 patients with abnormal 24-hour EEGs. In the regression analysis exploring the crude associations, we found significant correlations between 6 EEG variables and the duration of seizure freedom indicating that shorter duration of seizure freedom was associated with higher spike densities and longer paroxysms. These associations were not affected by confounders such as syndrome, age at EEG, age at epilepsy onset, sex, duration of epilepsy, or number of antiepileptic drugs. Higher densities and longer durations of ...Continue Reading

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Jul 1, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Udaya SeneviratneWendyl D'Souza
Oct 11, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Udaya SeneviratneWendyl D'Souza

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Citations

Jan 26, 2018·Current Opinion in Neurology·Philippa KarolyMark Cook
Jul 2, 2020·Risk Management and Healthcare Policy·Yiqian ChenJiayin Miao
May 3, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E SokolovF J Mateen
Mar 5, 2021·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Tasneem F Hasan, William O Tatum
Nov 5, 2019·Epilepsy & Behavior : E&B·Shannon ClarkeWendyl D'Souza

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