EEG findings of reduced neural synchronization during visual integration in schizophrenia

PloS One
J K WynnM F Green

Abstract

Schizophrenia patients exhibit well-documented visual processing deficits. One area of disruption is visual integration, the ability to form global objects from local elements. However, most studies of visual integration in schizophrenia have been conducted in the context of an active attention task, which may influence the findings. In this study we examined visual integration using electroencephalography (EEG) in a passive task to elucidate neural mechanisms associated with poor visual integration. Forty-six schizophrenia patients and 30 healthy controls had EEG recorded while passively viewing figures comprised of real, illusory, or no contours. We examined visual P100, N100, and P200 event-related potential (ERP) components, as well as neural synchronization in the gamma (30-60 Hz) band assessed by the EEG phase locking factor (PLF). The N100 was significantly larger to illusory vs. no contour, and illusory vs. real contour stimuli while the P200 was larger only to real vs. illusory stimuli; there were no significant interactions with group. Compared to controls, patients failed to show increased phase locking to illusory versus no contours between 40-60 Hz. Also, controls, but not patients, had larger PLF between 30-40 Hz ...Continue Reading

References

Apr 1, 1976·Scientific American·G Kanizsa
Oct 1, 1991·The American Journal of Psychiatry·D C Javitt, S R Zukin
Apr 1, 1983·Electroencephalography and Clinical Neurophysiology·G GrattonE Donchin
May 14, 1999·Trends in Cognitive Sciences·C Tallon-Baudry, O Bertrand
Jun 23, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·C S HerrmannE Pfeifer
Jan 11, 2000·Journal of Psychiatric Research·J W OlneyN B Farber
Mar 20, 2001·Nature Reviews. Neuroscience·C J McBain, A Fisahn
Apr 17, 2001·Neuroreport·C S Herrmann, V Bosch
Nov 3, 2001·The American Journal of Psychiatry·G M DonigerD C Javitt
Jul 26, 2003·Brain Research. Cognitive Brain Research·Cyril PernetPierre Celsis
Nov 20, 2003·Trends in Neurosciences·Miles A Whittington, Roger D Traub
Aug 27, 2004·Schizophrenia Research·L Elliot HongGunvant K Thaker
Nov 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kevin M SpencerRobert W McCarley
Aug 4, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter J UhlhaasEugenio Rodriguez
Nov 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Micah M MurrayJohn J Foxe
May 10, 2008·Neuron·Shlomit Yuval-GreenbergLeon Y Deouell
Jun 14, 2008·Biological Psychiatry·Pamela D ButlerSteven C Dakin
Mar 31, 2009·Annual Review of Clinical Psychology·Daniel C Javitt
Jan 22, 2011·Computational Intelligence and Neuroscience·Robert OostenveldJan-Mathijs Schoffelen
Jun 21, 2011·Neuropsychologia·Alexis D J MakinWael El-Deredy
Sep 14, 2011·Neuropsychobiology·Chisako IkedaHeii Arai
Oct 25, 2011·Schizophrenia Bulletin·Steven M SilversteinMilton E Strauss
Dec 12, 2012·Psychological Science·Martijn E WokkeVictor A F Lamme
Feb 12, 2014·Neuropsychologia·Brian P KeaneSteven M Silverstein
Feb 20, 2014·Frontiers in Psychology·Kevin M Spencer, Shahab Ghorashi

❮ Previous
Next ❯

Citations

Oct 21, 2015·Sleep Science·Edgar Garcia-RillFrancisco J Urbano
Apr 2, 2016·Physiological Reports·Stasia D'OnofrioEdgar Garcia-Rill
Apr 15, 2017·Physiological Reports·Stasia D'OnofrioEdgar Garcia-Rill
Nov 6, 2015·Frontiers in Psychiatry·Shahab Ghorashi, Kevin M Spencer
Jun 18, 2020·Frontiers in Neuroscience·Aadith VittalaVaishnav Krishnan
May 18, 2019·Applied Psychophysiology and Biofeedback·Jean-Arthur Micoulaud-FranchiFrançois Vialatte

❮ Previous
Next ❯

Software Mentioned

BrainVision Analyzer
Matlab
FieldTrip

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here