EEG-fMRI study of the interictal epileptic activity in patients with partial epilepsy

Journal of the Neurological Sciences
Yonghong LiuDong Zhou

Abstract

To investigate Blood Oxygen Level Dependent (BOLD) responses to interictal epileptic discharges (IEDs) during EEG-correlated functional MRI (EEG-fMRI) in patients with partial epilepsy. We studied eight patients who had a diagnosis of partial epilepsy and active spiking on routine scalp EEG recording. Sessions of continuous EEG-fMRI were recorded, and spikes (identified after online artifact removal) were used as events in the fMRI analysis. Regions of BOLD signal change in response to interictal epileptic discharge were assessed and epileptogenic zone localization was electroclinically identified. Eight patients with partial epilepsy were recruited (6 males, 2 females, mean age 18.5, mean onset age range 0.5-29). Two who underwent EEG-fMRI were excluded from further analysis: one due to absence of epileptic discharges, the other due to excessive head motion. Eight sessions of EEG-fMRI scanning in 6 patients were obtained: 6 with activation and deactivation, one with activation only, and one with deactivation only. Focal activations corresponding to electroclinical localization occurred in 7 sessions, 5 of which were maximal. Maximally activated areas detected by EEG-fMRI in patients with partial epilepsy appear to be concordan...Continue Reading

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Citations

Nov 26, 2009·Pediatric Radiology·James L Leach, Scott K Holland
May 18, 2010·Magnetic Resonance Imaging·Petra J van HoudtPauly P W Ossenblok
Jan 15, 2010·Magnetic Resonance Imaging·Mirco CosottiniLuigi Murri
Jul 28, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Danny FlanaganGraeme D Jackson
May 15, 2021·Frontiers in Neurology·Seyyed Mostafa SadjadiHamid Soltanian-Zadeh

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