EEG gamma frequency and sleep-wake scoring in mice: comparing two types of supervised classifiers

Brain Research
Jurij BrankackAndreas Draguhn

Abstract

There is growing interest in sleep research and increasing demand for screening of circadian rhythms in genetically modified animals. This requires reliable sleep stage scoring programs. Present solutions suffer, however, from the lack of flexible adaptation to experimental conditions and unreliable selection of stage-discriminating variables. EEG was recorded in freely moving C57BL/6 mice and different sets of frequency variables were used for analysis. Parameters included conventional power spectral density functions as well as period-amplitude analysis. Manual staging was compared with the performance of two different supervised classifiers, linear discriminant analysis (LDA) and Classification Tree. Gamma activity was particularly high during REM (rapid eye movements) sleep and waking. Four out of 73 variables were most effective for sleep-wake stage separation: amplitudes of upper gamma-, delta- and upper theta-frequency bands and neck muscle EMG. Using small sets of training data, LDA produced better results than Classification Tree or a conventional threshold formula. Changing epoch duration (4 to 10s) had only minor effects on performance with 8 to 10s yielding the best results. Gamma and upper theta activity during REM...Continue Reading

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Citations

May 20, 2014·PloS One·Elena AmendolaCornelius T Gross
Mar 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lori PanossianSigrid Veasey
Nov 20, 2015·Journal of Neuroscience Methods·Farid YaghoubySridhar Sunderam
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Apr 30, 2013·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Genshiro A SunagawaHiroki R Ueda
Jul 21, 2012·Journal of Sleep Research·Jurij BrankačkAndreas Draguhn
Apr 29, 2016·International Journal of Neural Systems·Farid YaghoubySridhar Sunderam
Oct 16, 2012·Neuropharmacology·Claudia ScheffzükJurij Brankačk
Aug 6, 2014·Journal of Neuroscience Methods·Stefano BastianiniGiovanna Zoccoli
Jun 2, 2016·Neural Plasticity·Jakob JessbergerAndreas Draguhn
Feb 26, 2016·Scientific Reports·Xiaomin ZhangAndreas Draguhn
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Jul 2, 2021·Neurobiology of Sleep and Circadian Rhythms·Rama DibValérie Mongrain
Jul 24, 2021·Sleep·Maximilian HammerAdriano B L Tort

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