EEG Global Field Power spectrum changes after a single dose of atypical antipsychotics in healthy volunteers

Brain Topography
Keizo YamadaT Kinoshita

Abstract

Effects of four novel atypical antipsychotic drugs (olanzapine, perospirone, quetiapine, and risperidone) on scalp-recorded multi-channel EEGs were compared with two conventional antipsychotic drugs (chlorpromazine and haloperidol) and placebo in 14 healthy male volunteers. All subjects went through seven sessions. In each session, EEGs were recorded before and 2, 4 and 6 hours after drug administration. Global Field Power (GFP) in delta frequency band (1.5-6 Hz) increased around the time of peak serum concentration of quetiapine and risperidone compared to baseline. The increase of GFP in delta activity after quetiapine was significantly prominent in comparison to two other atypical antipsychotic drugs, perospirone and olanzapine, as well as to typical antipsychotic drugs, chlorpromazine and haloperidol (p<0.05). The increase in GFP of delta after risperidone was more prominent in comparison to after haloperidol (p<0.05). The greater sedative effects after quetiapine and risperidone may reflect the high affinity to A1 and H1 receptor bindings of these drugs. According to Low Resolution Electromagnetic Tomography (LORETA), olanzapine increased the delta in the posterior region indicating a frontal shift of brain activity, sugge...Continue Reading

Citations

Mar 25, 2011·European Archives of Psychiatry and Clinical Neuroscience·Detlef DegnerUdo Reulbach
May 13, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Peter J Siekmeier, Steven M Stufflebeam
Dec 12, 2013·Biomarkers in Medicine·Brett A EnglishLarry Ereshefsky
Jun 1, 2006·Clinical EEG and Neuroscience·Armida MucciSilvana Galderisi
Sep 24, 2010·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Ryouhei IshiiMasatoshi Takeda
Aug 26, 2006·Medical & Biological Engineering & Computing·William L ManerRobert E Garfield
Dec 28, 2017·The European Journal of Neuroscience·Anna CastelnovoArmando D'Agostino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here