Aug 1, 1977

EEG in presenile dementia related to cerebral blood flow and autopsy findings

Acta Neurologica Scandinavica
G JóhannessonD H Ingvar

Abstract

EEG, regional cerebral blood flow (rCBF) and neuropathological autopsy data were studied in 17 patients with presenile dementia. RCBF was measured in 14 cases using the intra-arterial-133-Xenon clearance technique. The neuropathological study included semi-serial whole brain microscopical sections in which the severity and regional distribution of the neuronal degeneration was studied, particularly in the cortex and the brain stem. There were two main diagnostic groups, seven cases of Alzheimer's disease and five cases with a cortical atrophy of the Pick (DFT) type. Both groups showed fronto-temporal cortical degeneration. In addition the Alzheimer group showed severe postcentral and posterior-temporal loss of neurons. There were also three cases with degenerative changes, suggesting Jacob-Creutzfeldt's disease. The Alzheimer cases had EEG abnormalities which progressed slowly. In contrast, the Pick (DFT) patients had normal EEGs which remained so even late in the course when the signs of dementia were marked. A positive correlation between rCBF reduction in postcentral areas (as evidence of neuronal loss in these regions) and an increase of EEG abnormality could be established. Degenerative changes confined to frontal and ante...Continue Reading

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Mentioned in this Paper

Senile Paranoid Dementia
Familial Alzheimer Disease (FAD)
Cerebral Blood Flow Imaging
Cerebral Atrophy
Cortex Bone Disorders
Abnormal Degeneration
Adrenal Cortex Diseases
Myopia, Degenerative
Autopsy
Neurons

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