EEG Radiotelemetry in Small Laboratory Rodents: A Powerful State-of-the Art Approach in Neuropsychiatric, Neurodegenerative, and Epilepsy Research

Neural Plasticity
Andreas LundtMarco Weiergräber

Abstract

EEG radiotelemetry plays an important role in the neurological characterization of transgenic mouse models of neuropsychiatric and neurodegenerative diseases as well as epilepsies providing valuable insights into underlying pathophysiological mechanisms and thereby facilitating the development of new translational approaches. We elaborate on the major advantages of nonrestraining EEG radiotelemetry in contrast to restraining procedures such as tethered systems or jacket systems containing recorders. Whereas a main disadvantage of the latter is their unphysiological, restraining character, telemetric EEG recording overcomes these disadvantages. It allows precise and highly sensitive measurement under various physiological and pathophysiological conditions. Here we present a detailed description of a straightforward successful, quick, and efficient technique for intraperitoneal as well as subcutaneous pouch implantation of a standard radiofrequency transmitter in mice and rats. We further present computerized 3D-stereotaxic placement of both epidural and deep intracerebral electrodes. Preoperative preparation of mice and rats, suitable anaesthesia, and postoperative treatment and pain management are described in detail. A special...Continue Reading

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Citations

May 14, 2016·Journal of Neuroscience Methods·Marco WeiergräberRalf Müller
Jun 12, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cameron H GoodVincent Mysliwiec
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Oct 14, 2020·Scientific Reports·Ning Cheng, Kartikeya Murari
Aug 22, 2020·Journal of Neuroscience Methods·J S VuongA Devergnas

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Methods Mentioned

BETA
transgenic
dissection

Software Mentioned

Dataquest ART
StereoDrive
BioSigRZ
Dataquest

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