Oct 24, 1998

EEG sleep in African-American patients with major depression: a historical case control study

Depression and Anxiety
D E GilesD J Kupfer


This study was designed to evaluate the effect of race, specifically African-American, on electroencephalographic (EEG) sleep and clinical symptom profile in unipolar major depression. A clinical research database was used to identify appropriate subjects and a double-matched historical case-control design was implemented. African-American depression patients were double matched within protocol to Euro-American depressed patients. Age, sex, and protocol of origin were matching variables. African-American depressed patients had less total sleep, less slow wave sleep, more stage 2 sleep, longer rapid eye movement (REM) sleep latency, less REM sleep, and lower REM density than Euro-American depressed patients. African-American depressed patients did not differ from Euro-American patients in symptom severity, age of onset, number of episodes, socio-economic status, and, as planned, did not differ in age and sex distribution. Depressive symptom constellation also did not distinguish the two groups. African-American depressed patients demonstrated differences in EEG sleep profile, with less total sleep, overall lighter nonREM sleep, and relatively preserved REM sleep, despite a clinical symptom profile that did not differ from Euro-A...Continue Reading

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Mentioned in this Paper

Surface Electromyography
Depressed - Symptom
Sleep, Slow-Wave
African Continental Ancestry Group
Depressive Disorder
European Continental Ancestry Group
Biologic Preservation
African American
Nested Case-Control Studies

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