EEG Spectral Features Discriminate between Alzheimer's and Vascular Dementia

Frontiers in Neurology
Emanuel NetoTom Eichele

Abstract

Alzheimer's disease (AD) and vascular dementia (VaD) present with similar clinical symptoms of cognitive decline, but the underlying pathophysiological mechanisms differ. To determine whether clinical electroencephalography (EEG) can provide information relevant to discriminate between these diagnoses, we used quantitative EEG analysis to compare the spectra between non-medicated patients with AD (n = 77) and VaD (n = 77) and healthy elderly normal controls (NC) (n = 77). We use curve-fitting with a combination of a power loss and Gaussian function to model the averaged resting-state spectra of each EEG channel extracting six parameters. We assessed the performance of our model and tested the extracted parameters for group differentiation. We performed regression analysis in a multivariate analysis of covariance with group, age, gender, and number of epochs as predictors and further explored the topographical group differences with pair-wise contrasts. Significant topographical differences between the groups were found in several of the extracted features. Both AD and VaD groups showed increased delta power when compared to NC, whereas the AD patients showed a decrease in alpha power for occipital and temporal regions when comp...Continue Reading

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Citations

Dec 15, 2016·Frontiers in Aging Neuroscience·Emanuel NetoTom Eichele
Jun 22, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Chao WangWutao Lou
Jul 13, 2017·The European Journal of Neuroscience·Abigail DickinsonShafali Spurling Jeste
Aug 17, 2019·Autism Research : Official Journal of the International Society for Autism Research·Abigail DickinsonShafali S Jeste
Jun 17, 2020·Clinical EEG and Neuroscience·Malihe MoghadamiJavad Salehi Fadardi
May 13, 2019·Medical & Biological Engineering & Computing·Jude Pj SavarrajMark A DeCoster
Jul 6, 2019·Brain Topography·Fengrui ZhangLi Hu
Jul 16, 2019·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Luke TaitMarc Goodfellow
May 14, 2021·Computational and Mathematical Methods in Medicine·Morteza AminiMahshad Ouchani
Jun 8, 2021·Journal of Alzheimer's Disease : JAD·Fabrizio VecchioPaolo Maria Rossini

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

MANCOVAN
EEGLab
Mathworks
Matlab

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