EepR Mediates Secreted-Protein Production, Desiccation Survival, and Proliferation in a Corneal Infection Model

Infection and Immunity
Kimberly M BrothersRobert M Q Shanks

Abstract

Serratia marcescens is a soil- and water-derived bacterium that secretes several host-directed factors and causes hospital infections and community-acquired ocular infections. The putative two-component regulatory system composed of EepR and EepS regulates hemolysis and swarming motility through transcriptional control of the swrW gene and pigment production through control of the pigA-pigN operon. Here, we identify and characterize a role for EepR in regulation of exoenzyme production, stress survival, cytotoxicity to human epithelial cells, and virulence. Genetic analysis supports the model that EepR is in a common pathway with the widely conserved cyclic-AMP receptor protein that regulates protease production. Together, these data introduce a novel regulator of host-pathogen interactions and secreted-protein production.

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Citations

Aug 17, 2016·Scientific Reports·Eric G RomanowskiRobert M Q Shanks
Jul 20, 2018·PloS One·Jennifer Hage-HülsmannAnita Loeschcke
Mar 10, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Wael A H HegazyWafaa E Soliman
Jun 3, 2021·Microorganisms·Ahdab N KhayyatHisham A Abbas

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