Efavirenz but Not Atazanavir/Ritonavir Significantly Reduces Atovaquone Concentrations in HIV-Infected Subjects

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Mónica M CalderónJoseph A Kovacs

Abstract

The current study was conducted to determine if efavirenz (EFV) or atazanavir/ritonavir (ATV/r)-based combination antiretroviral therapy (cART) impacted steady-state atovaquone plasma concentrations in human immunodeficiency virus (HIV)-infected patients receiving treatment doses of atovaquone. Thirty HIV-infected volunteers were recruited, 10 taking no cART and 10 each taking cART that included EFV or ATV/r. Subjects were randomly assigned to atovaquone 750 mg twice daily (BID) for 14 days followed by atovaquone 1500 mg BID for 14 days, or vice-versa, with a washout period in between. On day 14 of each phase, blood was sampled for pharmacokinetic studies, and the area under the concentration-time curve (AUCτ) and average concentration (C avg) were calculated and compared using an unpaired t test. Twenty-nine subjects completed both dosing cohorts. Subjects receiving EFV-based cART had 47% and 44% lower atovaquone AUCτ than subjects not receiving cART at atovaquone doses of 750 mg BID and 1500 mg BID, respectively (P≤ .01). Only 5 of 10 subjects receiving EFV-based cART plus atovaquone 750 mg BID had an atovaquone C avg>15 µg/mL, which has previously been associated with successful treatment of Pneumocystis jirovecipneumonia. A...Continue Reading

References

Mar 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R A TorresJ Scott
Sep 2, 1998·British Journal of Clinical Pharmacology·D OuelletG R Granneman
Dec 22, 2005·The Annals of Pharmacotherapy·Nancy L SheehanJames Allan
Aug 8, 2006·Clinical Pharmacology and Therapeutics·Manon J van der LeeDavid M Burger
Jul 23, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gopal KrishnaJ McLeod

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