Effect and mechanism of verbascoside on hypoxic memory injury in plateau

Phytotherapy Research : PTR
Maoxing LiYan Qiu

Abstract

Verbascoside is a water-soluble natural phenylethanoid glycoside and distributes widely in plants. It has been proved with antioxidant, neuroprotective, anti-inflammatory, antibacterial, and immunomodulatory bioactivities. In this experiment, the effect and mechanism of verbascoside on hypoxic memory injury were studied in a low-pressure and low-oxygen chamber. Verbascoside (50, 150, and 300 mg/kg) was intragastrically administered once a day for 7 days. On the fourth day, rats were placed in the chamber to simulate a 7,500 m high-altitude environment The eight-arm maze was used to test the memory ability. The levels of MDA, GSH, and T-SOD in plasma, brain-NH, and hippocampus were detected. The mRNA expression of mTOR, P70S6K, and 4E-BP1 in the hippocampus tissue was determined by PCR. The protein expression of P-mTOR, P-P70S6K, P-4E-BP1, and Cleaved Caspase-3 in the hippocampus tissue was determined by western blot. The results indicated that administration with verbascoside could obviously reduce the working memory error, reference memory error, total errors, and total time; relieve the neuron damage in CA1 region of the hippocampus; and decrease the oxidative stress correlation enzyme activity in plasma, brain, and hippocamp...Continue Reading

References

Sep 17, 2002·European Journal of Pharmacology·Guo-Qing ShengChang-Ling Li
Jun 5, 2003·The Journal of Biological Chemistry·Andrew M ArshamM Celeste Simon
Jan 6, 2006·Biological & Pharmaceutical Bulletin·Ki Yong LeeYoung Choong Kim
Aug 17, 2006·Neurochemistry International·Panchanan MaitiG Ilavazhagan
Jun 21, 2007·Respiratory Physiology & Neurobiology·María Rivera-ChLuis Huicho
Nov 12, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Emanuela EspositoSalvatore Cuzzocrea
Sep 3, 2010·Phytotherapy Research : PTR·Lorenza SperanzaAlfredo Grilli
Jan 25, 2012·Journal of Agricultural and Food Chemistry·Angela CardinaliVincenzo Lattanzio
Jul 19, 2012·Psychophysiology·Valdir de Aquino LemosMarco Túlio de Mello
Oct 17, 2012·Aviation, Space, and Environmental Medicine·Frank A PetrassiSteven J Gaydos
Sep 18, 2013·Learning & Memory·Tyson E GraberWayne S Sossin
Oct 22, 2013·Otolaryngologic Clinics of North America·Derrick T Lin, Alice C Lin
Jul 23, 2014·Biotechnology Advances·Kalina AlipievaMilen I Georgiev
Oct 11, 2015·International Immunopharmacology·Sun-Young NamHyun-Ja Jeong
Nov 26, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·David I Sandberg, Marcia L Kerr

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