Abstract
Verbascoside is a water-soluble natural phenylethanoid glycoside and distributes widely in plants. It has been proved with antioxidant, neuroprotective, anti-inflammatory, antibacterial, and immunomodulatory bioactivities. In this experiment, the effect and mechanism of verbascoside on hypoxic memory injury were studied in a low-pressure and low-oxygen chamber. Verbascoside (50, 150, and 300 mg/kg) was intragastrically administered once a day for 7 days. On the fourth day, rats were placed in the chamber to simulate a 7,500 m high-altitude environment The eight-arm maze was used to test the memory ability. The levels of MDA, GSH, and T-SOD in plasma, brain-NH, and hippocampus were detected. The mRNA expression of mTOR, P70S6K, and 4E-BP1 in the hippocampus tissue was determined by PCR. The protein expression of P-mTOR, P-P70S6K, P-4E-BP1, and Cleaved Caspase-3 in the hippocampus tissue was determined by western blot. The results indicated that administration with verbascoside could obviously reduce the working memory error, reference memory error, total errors, and total time; relieve the neuron damage in CA1 region of the hippocampus; and decrease the oxidative stress correlation enzyme activity in plasma, brain, and hippocamp...Continue Reading
References
Sep 17, 2002·European Journal of Pharmacology·Guo-Qing ShengChang-Ling Li
Jun 5, 2003·The Journal of Biological Chemistry·Andrew M ArshamM Celeste Simon
Jan 6, 2006·Biological & Pharmaceutical Bulletin·Ki Yong LeeYoung Choong Kim
Feb 21, 2006·Experimental Cell Research·Catherine AlexiaAndré Groyer
May 2, 2006·Molecular and Cellular Biology·Eileen ConnollyRobert J Schneider
Aug 17, 2006·Neurochemistry International·Panchanan MaitiG Ilavazhagan
Jun 21, 2007·Respiratory Physiology & Neurobiology·María Rivera-ChLuis Huicho
Nov 12, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Emanuela EspositoSalvatore Cuzzocrea
Sep 3, 2010·Phytotherapy Research : PTR·Lorenza SperanzaAlfredo Grilli
Aug 31, 2011·Brain Research·Mehrak Javadi-PaydarAhmad Reza Dehpour
Jan 25, 2012·Journal of Agricultural and Food Chemistry·Angela CardinaliVincenzo Lattanzio
Jul 4, 2012·Neuroscience·J HalloranV Galvan
Jul 19, 2012·Psychophysiology·Valdir de Aquino LemosMarco Túlio de Mello
Oct 17, 2012·Aviation, Space, and Environmental Medicine·Frank A PetrassiSteven J Gaydos
Mar 16, 2013·Journal of Natural Medicines·Hideko MotojimaHiroko Isoda
Sep 18, 2013·Learning & Memory·Tyson E GraberWayne S Sossin
Oct 22, 2013·Otolaryngologic Clinics of North America·Derrick T Lin, Alice C Lin
Jul 23, 2014·Biotechnology Advances·Kalina AlipievaMilen I Georgiev
Apr 23, 2015·Phytotherapy Research : PTR·Li GaoMing Yan
Oct 11, 2015·International Immunopharmacology·Sun-Young NamHyun-Ja Jeong
Nov 26, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·David I Sandberg, Marcia L Kerr
Jan 31, 2016·Physiology & Behavior·Baozhu ZhouXianmin Wang
Jun 22, 2016·Food & Function·Xun SongZhen-Dan He
Citations
Apr 17, 2020·Phytotherapy Research : PTR·Jipeng ShiMaoxing Li
Apr 18, 2020·Hereditas·Yue ChangHai Li
Apr 4, 2021·Antioxidants·Antonella AngiolilloAlfonso Di Costanzo
Jun 27, 2021·Archives of Biochemistry and Biophysics·Yuanyuan WuWeisheng Feng