Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson's Disease

Evidence-based Complementary and Alternative Medicine : ECAM
Fang WangWei Zhang

Abstract

Objectives. To explore effectiveness and mechanisms of electroacupuncture (EA) add-on treatment in Parkinson's disease (PD) patients. Methods. Fifty PD patients were randomly assigned to drug plus EA (D + EA) group and drug alone (D) group. Subjects in D + EA group received stimulation in points of bilateral fengfu, fengchi, hegu, and central dazhui. Participants were evaluated by scales for motor and nonmotor symptoms. Levels of neuroinflammatory factors and neurotransmitters in serum were detected. Results. EA add-on treatment remarkably reduced scores of Unified Parkinson's Disease Rating Scale (UPDRS) III and its subitems of tremor, rigidity, and bradykinesia and conspicuously decreased UPDRS III scores in patients with bradykinesia-rigidity and mixed types and mild severity. Depression and sleep disturbances were eased, which were reflected by decreased scores of Hamilton Depression Rating Scale, Pittsburgh Sleep Quality Index, and elevated noradrenaline level. Effects of EA add-on treatment on motor symptoms and sleep disturbances were superior to drug alone treatment, markedly improving life quality of PD patients. EA add-on treatment decreased nitric oxide level in serum. Conclusions. EA add-on treatment is effective on...Continue Reading

References

Aug 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·D R Rajput
Apr 1, 1997·Chemical Research in Toxicology·L J KennedyP C Dedon
Aug 17, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·A SchragN Quinn
Jun 22, 2002·Annals of the New York Academy of Sciences·Alvaro G Estévez, Joaquín Jordán
Jul 3, 2002·Experimental Neurology·Deborah J Clarke, Richard L Branton
Sep 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Lisa M ShulmanJanet Konefal
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Mar 3, 2004·The Journal of Neuropsychiatry and Clinical Neurosciences·D Warren SpenceColin M Shapiro
May 11, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Adrian CristianRuth H Walker
Aug 6, 2005·Progress in Neurobiology·Michelle L Block, Jau-Shyong Hong
Dec 21, 2006·Nature Reviews. Neuroscience·Michelle L BlockJau-Shyong Hong
Mar 3, 2007·Occupational and Environmental Medicine·F D DickUNKNOWN Geoparkinson study group
Jan 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fu-Wen ZhouFu-Ming Zhou
Dec 23, 2008·Sleep Medicine Reviews·Wei HuangDonald L Bliwise
Feb 12, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A DegardinD Devos
Mar 21, 2009·Mediators of Inflammation·Deniz TuncelIsmail Toru
Nov 20, 2009·The International Journal of Neuroscience·Yong HuangGustav Wik
Dec 2, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Laurence Nègre-PagèsUNKNOWN DoPaMiP Study Group
Mar 5, 2010·The International Journal of Neuroscience·Yong HuangGustav Wik
May 22, 2010·Clinics in Chest Medicine·Brandon S Lu, Phyllis C Zee
Oct 6, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·David A GallagherAnette Schrag
Oct 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suzanne HoodShimon Amir
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Nov 29, 2011·Journal of the Neurological Sciences·Nico J Diederich, Deborah J McIntyre
Feb 10, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Li-Rong HuoXiao-Min Wang
May 15, 2012·Current Neurology and Neuroscience Reports·Christopher J Barnum, Malú G Tansey
May 29, 2012·Parkinsonism & Related Disorders·Seung-Yeon ChoSeong-Uk Park
Aug 21, 2012·Clinical Neurology and Neurosurgery·Eman M KhedrKhaled M A El Beh
Sep 5, 2012·CNS Neuroscience & Therapeutics·Sujung YeoSung-Hoon Kim
Jan 16, 2013·Neurology·Tien K KhooDavid J Burn
Mar 9, 2013·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Dhananjay Vijay Arankalle, Pradeep M K Nair
Nov 13, 2013·International Review of Neurobiology·Bai-Yun ZengPeter Jenner

❮ Previous
Next ❯

Citations

Aug 16, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Min SunXiao-Min Wang
Jan 18, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Klaus SeppiUNKNOWN the collaborators of the Parkinson's Disease Update on Non-Motor Symptoms Study Group on behalf of the Movement Disorders So
Mar 4, 2017·Journal of Acupuncture and Meridian Studies·Fábio Henrique de Amorim AroxaNadja Maria Jorge Asano
May 24, 2020·Complementary Therapies in Medicine·Liujiao CaoKehu Yang

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS Statistics
Nonmotor Symptoms Quest ( NMSQ )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.