Effect In Vitro of Antiparasitic Drugs on Microbial Inhibitor Test Responses for Screening Antibiotic Residues in Goat's Milk

Journal of Food Protection
T RomeroM P Molina

Abstract

Microbial inhibitor tests are widely used to screen antibiotic residues in milk; however, these tests are nonspecific and may be affected by various substances capable of inhibiting the growth of the test microorganism. The objective of this study was to determine the effect of antiparasitic drugs in goat's milk on the microbial inhibitor test response. Raw antibiotic-free milk from Murciano-Granadina goats was supplemented with eight concentrations of seven antiparasitic substances (albendazole, 10 to 170 mg/kg; closantel, 1 to 140 mg/kg; diclazuril, 8 to 45 mg/kg; febendazole, 10 to 140 mg/kg; levamisole, 40 to 440 mg/kg; diazinon, 8 to 45 mg/kg; and ivermectin, 40 to 200 mg/kg). Twelve replicates for each concentration were analyzed with three microbial inhibitor tests: BRT MRL, Delvotest SP-NT MSC, and Eclipse 100. The results were interpreted visually (negative or positive). Using a logistic regression model, the concentrations of the antiparasitic drugs producing 5% (IC5), 10% (IC10), and 50% (IC50) positive results were determined. In general, the Eclipse 100 test was less sensitive to the effect of antiparasitic substances; the inhibitory concentrations of almost all the drugs assayed were higher than those for other te...Continue Reading

References

Dec 1, 1990·Journal of Veterinary Pharmacology and Therapeutics·E W ScottQ A McKellar
Jan 11, 2011·The Veterinary Clinics of North America. Food Animal Practice·John W Plant, Christopher J Lewis
Nov 30, 2011·Antioxidants & Redox Signaling·Chinmay Pal, Uday Bandyopadhyay
Jun 7, 2014·Journal of Veterinary Pharmacology and Therapeutics·S IezziF Imperiale
Jul 24, 2014·The Journal of Dairy Research·Tamara RomeroMaría Pilar Molina

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Citations

Sep 8, 2016·The Journal of Dairy Research·Tamara RomeroMaría Pilar Molina
Jul 31, 2019·Asian-Australasian Journal of Animal Sciences·Lucia Sepe, Anastasio Argüello
Sep 16, 2017·Journal of Food and Drug Analysis·Tamara RomeroMaría Pilar Molina

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