PMID: 15374302Mar 1, 1994Paper

Effect-kinetics on brain protection of two codergocrine-mesylate preparations (Aramexe retard and Hydergine) by EEG mapping and psychometry under hypoxia

Archives of Gerontology and Geriatrics
B SaletuG Zyhlarz

Abstract

In a double-blind, placebo-controlled study the effect-kinetics on brain protection of a new retard formulation of codergocrine-mesylate (CDM) (Aramexe retard, 5 mg) were investigated and compared with a standard CDM drug (5 mg Hydergine) utilizing blood gas analysis, EEG mapping and psychometry. A transient, reversible hypoxic hypoxidosis (i.e. impairment of cerebral metabolism due to hypoxia) was experimentally induced by a fixed gas combination of 9.8% oxygen (O(2)) and 90.2% nitrogen (N(2)) (found at an altitude of 6000 m), which was inhaled for 23 min under normobaric conditions by 18 healthy volunteers. After an adaptation session they received randomized 5 mg Aramexe retard, 5 mg Hydergine and placebo. Evaluation of blood gases, EEG mapping and psychometry was carried out at 0,2, 4,6, and 8 h after oral drug administration - each time under normoxic and hypoxic conditions. Blood gas analysis demonstrated a drop in SaO(2) from 99% under normoxia to 70% under hypoxia, in Po(2) from 100 to 33 mmHg, and in Pco(2) from 36 to 31 mmHg, while pH increased from 7.43 to 7.48. Base excess and standard bicarbonate remained stable. Under hypoxia EEG mapping exhibited an increase in delta/theta, a decrease of alpha and increase of bet...Continue Reading

References

Mar 1, 1977·Electroencephalography and Clinical Neurophysiology·A M Gurvitch, D A Ginsburg
Oct 15, 1992·Biological Psychiatry·B SaletuF Böhmer
Jan 1, 1991·Alzheimer Disease and Associated Disorders·B SaletuG Litschauer
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May 1, 1981·Electroencephalography and Clinical Neurophysiology·F H DuffyJ L Burchfiel
Jan 1, 1982·Electroencephalography and Clinical Neurophysiology·T GasserJ Möcks

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Citations

Jun 19, 2001·The Cochrane Database of Systematic Reviews·J OlinS Luczak
Jan 9, 1999·Proceedings. Biological Sciences·T H Clutton-BrockJ D Skinner
May 5, 2000·The Cochrane Database of Systematic Reviews·J OlinS Luczak

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