Abstract
Elevated blood pressure is a major preventable cause of cardiovascular diseases. Alcohol consumption is a well-known risk factor of elevated blood pressure. The aldehyde dehydrogenase 2 (ALDH2) polymorphism is common in Eastern Asians, and inactive ALDH2 genotypes are associated with both avoiding alcohol consumption and aldehyde accumulation. Therefore, this study assessed the associations between alcohol consumption and hypertension and blood pressure according to the ALDH2 genotypes. This study consists of 8,526 participants in the Dong-gu Study. Multivariate logistic regression was used to calculate the odds ratio (OR) according to alcohol consumption after stratifying by gender and ALDH2 genotypes. Multivariate linear regression was performed to estimate the systolic blood pressure (SBP) and diastolic blood pressure (DBP) according to the amount of alcohol consumed. In men, alcohol consumption was positively associated with both SBP and DBP in active ALDH2 carriers, but not in inactive ALDH2 carriers. In active ALDH2 carriers, compared to non-drinkers, the OR of hypertension was 1.16 (95% confidence interval [CI], 0.91-1.49) for < 1 drink/day, and 1.44 (95% CI, 1.15-1.80) for ≥ 1 drink/day in men. With each 1 drink/day inc...Continue Reading
References
Dec 1, 1982·Pharmacology, Biochemistry, and Behavior·E Hellström, O Tottmar
Apr 3, 2002·Annals of Internal Medicine·Seamus P WheltonJiang He
Mar 6, 2008·PLoS Medicine·Lina ChenSarah J Lewis
Jul 12, 2008·Alcoholism, Clinical and Experimental Research·Akira YokoyamaTetsuji Yokoyama
Jun 16, 2009·Epidemiology·Enrique F SchistermanRobert W Platt
Mar 5, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Fumihiko TakeuchiNorihiro Kato
Mar 19, 2013·International Journal of Epidemiology·Sun-Seog KweonJin-Su Choi
Apr 5, 2013·Alcoholism, Clinical and Experimental Research·Akira YokoyamaKatsuya Maruyama
Apr 26, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Wei Sen ZhangTai Hing Lam
Nov 28, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ellen E QuillenJoel Gelernter
Jun 20, 2014·World Journal of Cardiology·Katia Colombo MarchiCarlos Renato Tirapelli
Apr 2, 2015·PloS One·Ryuhei MaejimaMikko Salaspuro
Jul 18, 2015·Disease Markers·Minoru IsomuraToru Nabika
Sep 1, 2015·Environmental Health and Preventive Medicine·Mitsunori OtaTakahiko Katoh
Jan 18, 2017·JAMA : the Journal of the American Medical Association·Mohammad H ForouzanfarChristopher J L Murray
Sep 13, 2017·Scientific Reports·Cong MaQiang Zeng
Dec 19, 2017·The Lancet. Public Health·Michael RoereckeJürgen Rehm
Jan 13, 2018·Scientific Reports·Yoonsu ChoMin-Jeong Shin
Jun 29, 2018·Journal of the American Heart Association·Michael RoereckeJürgen Rehm
Citations
Aug 4, 2021·Journal of Korean Medical Science·Jung Ho YangMin Ho Shin
Oct 10, 2021·Journal of Bone and Mineral Metabolism·Chang Kyun ChoiMin-Ho Shin
Oct 12, 2021·Frontiers in Immunology·Yassine TaoufikFathia Mami-Chouaib