Effect of ω-3 Polyunsaturated Fatty Acids-Derived Bioactive Lipids on Metabolic Disorders.

Frontiers in Physiology
Jinjie DuanChunjiong Wang

Abstract

Arachidonic acid (ARA) is an important ω-6 polyunsaturated fatty acid (PUFA), and docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and n-3 docosapentaenoic acid (n-3 DPA) are three well-known ω-3 PUFAs. These fatty acids can be metabolized into a number of bioactive lipids. Eicosanoids derived from ARA have drawn great attention because of their important and complex biofunctions. Although EPA, DHA and n-3 DPA have also shown powerful biofunctions, we have fewer studies of metabolites derived from them than those from ARA. Recently, growing research has focused on the bioaction of ω-3 PUFA-derived metabolites, which indicates their great potential for treating metabolic disorders. Most of the functional studies of these bioactive lipids focused on their anti-inflammatory effects. However, several studies elucidated their direct effects on pancreatic β cells, hepatocytes, adipocytes, skeletal muscle cells, and endothelial cells. These researches revealed the importance of studying the functions of metabolites derived from ω-3 polyunsaturated fatty acids other than themselves. The current review summarizes research into the effects of ω-3 PUFA-derived oxylipins on metabolic disorders, including diabetes, non-alcoholic fatt...Continue Reading

References

Aug 28, 2004·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M de Lorgeril, P Salen
Jan 17, 2008·Progress in Lipid Research·Gerd Schmitz, Josef Ecker
Jun 5, 2008·Nutrition Reviews·Aliza H StarkRam Reifen
Feb 13, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ana González-PérizJoan Clària
May 23, 2009·Journal of the American College of Cardiology·Carl J LavieHector O Ventura
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sriram KrishnamoorthyCharles N Serhan
Nov 30, 2010·International Journal of Endocrinology·Chunjiong WangJichun Yang
Apr 12, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jason HellmannMatthew Spite
Oct 21, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Esther TitosJoan Clària
Nov 15, 2011·Biochemical and Biophysical Research Communications·Ryouta KogureShigeki Takeda
Oct 22, 2013·Diabetes & Metabolism·M Lafontan
Nov 20, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bibiana RiusJoan Clària
Dec 18, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ganesan MuraliViswanathan Saraswathi
Jan 21, 2014·Cell·Evan D Rosen, Bruce M Spiegelman
Mar 29, 2014·Journal of Lipid Research·Hidetoshi YamadaKen-Ichi Kimura
Jun 5, 2011·Journal of Diabetes Investigation·Takashi Matsuzaka, Hitoshi Shimano
Jan 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Cristina López-VicarioJoan Clària
Mar 17, 2015·Critical Reviews in Food Science and Nutrition·Aliza H StarkMichael A Crawford
Jun 13, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hui Gyu ParkJ Thomas Brenna
Jun 19, 2015·World Journal of Hepatology·Monjur Ahmed
Jul 22, 2015·The Journal of Experimental Medicine·Nan ChiangCharles N Serhan
Sep 17, 2015·Advances in Nutrition·Melissa GabbsHarold M Aukema
Dec 2, 2015·Journal of Diabetes·Jinlong HeDing Ai
Dec 29, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiMark Wymer
Feb 20, 2016·Circulation Research·Michael A Gimbrone, Guillermo García-Cardeña
Aug 18, 2016·Circulation Research·Joana R ViolaOliver Soehnlein
Nov 18, 2016·Nature Communications·Tania Quesada-LópezFrancesc Villarroya
Dec 21, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcelo O FreireThomas E Van Dyke
Jan 15, 2017·Journal of Neuroinflammation·Livia B PascoalLicio A Velloso
Jan 15, 2017·Biochimie·Ondrej Kuda
Feb 12, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Leyre Martínez-FernándezMaría J Moreno-Aliaga
Mar 31, 2017·Proceedings of the National Academy of Sciences of the United States of America·Thomas GobbettiMauro Perretti
Apr 5, 2017·The Journal of Clinical Investigation·Xinyun BiAllan Zijian Zhao

❮ Previous
Next ❯

Related Concepts

Related Papers

JPEN. Journal of Parenteral and Enteral Nutrition
Pascal L LangloisWilliam Manzanares
The American Journal of Clinical Nutrition
A David SmithHelga Refsum
Expert Opinion on Pharmacotherapy
Eli M Roth
© 2021 Meta ULC. All rights reserved