Effect of γ-Aminobutyric Acid-Chitosan Nanoparticles on Glucose Homeostasis in Mice

ACS Omega
Yuangang LiuMengyi Wu

Abstract

Diabetes mellitus is the most common endocrine disease worldwide; hyperglycemia is a hallmark of this disease. To alleviate the pain caused by diabetes, developing and utilizing effective diabetic drugs to maintain or recover the function of the residual β-cells is an attractive therapeutic approach. γ-aminobutyric acid (GABA) has been shown to have such effects, but it is easy to have reduced GABA activity under physiological conditions. In the present study, GABA-chitosan nanoparticles (GABA-CS NPs) were prepared, and glucose homeostasis, pancreatic β-cell protection, and anti-inflammatory effects of GABA-CS NPs were investigated in vivo. The results showed that blood glucose levels and IL-1β levels in the GABA-CS NP-administered group were both significantly lower, whereas the PDX1 expression was significantly higher than that of the impaired group (p < 0.01). This indicates that GABA-CS NPs can efficiently maintain glucose homeostasis, protect β-cells, and inhibit inflammation. These nanoparticles have the potential to be applied for future diabetes theranostics.

References

May 5, 1999·Journal of Neuroimmunology·J TianD L Kaufman
Dec 28, 2002·Diabetes·Alexandra E ButlerPeter C Butler
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jide TianDaniel L Kaufman
Dec 13, 2005·Autonomic Neuroscience : Basic & Clinical·A GladkevichK V Melkonyan
Jan 10, 2006·Cell Metabolism·Elaine XuQinghua Wang
Jun 15, 2007·Diabetes·Peter In't VeldDaniel Pipeleers
Oct 18, 2008·Diabetes, Obesity & Metabolism·D PipeleersF Gorus
May 19, 2011·International Journal of Nanomedicine·Jun Jie WangShu Ling Wang
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nepton SoltaniQinghua Wang
Sep 11, 2012·Journal of Materials Science. Materials in Medicine·J ShilpaC S Paulose
Sep 18, 2013·Diabetes, Obesity & Metabolism·L DingC Mathieu
Feb 15, 2014·Nature Reviews. Drug Discovery·Amedeo VetereBridget K Wagner
Feb 14, 2015·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Yun WanGerald J Prud'homme
Mar 1, 2016·Acta Diabetologica·Silvia PellegriniLorenzo Piemonti
Jul 5, 2016·The Lancet. Diabetes & Endocrinology·Weiping Jia

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Citations

Aug 14, 2019·Journal of Biomaterials Science. Polymer Edition·Mingzhi ZhuYuangang Liu

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Methods Mentioned

BETA
scanning electron microscopy
ELISA

Software Mentioned

SPSS
Nanomeasure

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