Effect of γ-lactones and γ-lactams compounds on Streptococcus mutans biofilms

Journal of Applied Oral Science : Revista FOB
Mariane Beatriz SordiJ C M Souza

Abstract

Considering oral diseases, antibiofilm compounds can decrease the accumulation of pathogenic species such as Streptococcus mutans at micro-areas of teeth, dental restorations or implant-supported prostheses. To assess the effect of thirteen different novel lactam-based compounds on the inhibition of S. mutans biofilm formation. We synthesized compounds based on γ-lactones analogues from rubrolides by a mucochloric acid process and converted them into their corresponding γ-hydroxy-γ-lactams by a reaction with isobutylamine and propylamine. Compounds concentrations ranging from 0.17 up to 87.5 μg mL-1 were tested against S. mutans. We diluted the exponential cultures in TSB and incubated them (37°C) in the presence of different γ-lactones or γ-lactams dilutions. Afterwards, we measured the planktonic growth by optical density at 630 nm and therefore assessed the biofilm density by the crystal violet staining method. Twelve compounds were active against biofilm formation, showing no effect on bacterial viability. Only one compound was inactive against both planktonic and biofilm growth. The highest biofilm inhibition (inhibition rate above 60%) was obtained for two compounds while three other compounds revealed an inhibition rate ...Continue Reading

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Citations

Dec 11, 2019·Foods·Pedro Rodríguez-LópezMarta López Cabo
Dec 29, 2020·Journal of Periodontal Research·Pedro BarreirosJúlio C M Souza

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Methods Mentioned

BETA
scanning electron microscopy

Software Mentioned

STATISTICA

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