Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells.

British Journal of Cancer
N KuzumakiMichiko Narita

Abstract

It is becoming increasingly recognised that opioids are responsible for tumour growth. However, the effects of opioids on tumour growth have been controversial. The effects of κ-opioid receptor (KOR) agonist on the growth of non-small cell lung cancer (NSCLC) cells were assessed by a cell proliferation assay. Western blotting was performed to ascertain the mechanism by which treatment with KOR agonist suppresses tumour growth. Addition of the selective KOR agonist U50,488H to gefitinib-sensitive (HCC827) and gefitinib-resistant (H1975) NSCLC cells produced a concentration-dependent decrease in their growth. These effects were abolished by co-treatment with the selective KOR antagonist nor-BNI. Furthermore, the growth-inhibitory effect of gefitinib in HCC827 cells was further enhanced by co-treatment with U50,488H. With regard to the inhibition of tumour growth, the addition of U50, 488H to H1975 cells produced a concentration-dependent decrease in phosphorylated-glycogen synthase kinase 3β (p-GSK3β). The present results showed that stimulation of KOR reduces the growth of gefitinib-resistant NSCLC cells through the activation of GSK3β.

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Citations

Jul 12, 2017·Cancer Biology & Therapy·Archana MukhopadhyayJane V Aldrich
May 7, 2016·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Naoko KuzumakiMinoru Narita
May 8, 2013·Psychopharmacology·Richard M van RijnJennifer L Whistler
Sep 24, 2015·Bulletin of Experimental Biology and Medicine·Ya A KisarovaT A Korolenko
Jul 23, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A Carmona-BayonasJ A Virizuela
Jun 20, 2015·International Journal of Cancer. Journal International Du Cancer·Jheelam BanerjeeHildegard M Schuller
Jul 28, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Songye LiYiyun Huang
Oct 16, 2016·ACS Chemical Neuroscience·Zhengxin CaiYiyun Huang

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