Effect of 10 days of bedrest on metabolic and vascular insulin action: a study in individuals at risk for type 2 diabetes

Journal of Applied Physiology
M P SonneFlemming Dela

Abstract

Physical inactivity is a known risk factor for type 2 diabetes. We studied whole body and forearm insulin sensitivity in subjects at increased risk for type 2 diabetes [persons with low birth weight (LBW group; n = 20) and first-degree relatives to type 2 diabetic patients (FDR group; n = 13)] as well as a control (CON) group (n = 20) matched for body mass index, age, and physical activity levels before and after 10 days of bedrest. Subjects were studied by hyperinsulinemic isoglycemic clamp combined with arterial and deep venous catheterization of the forearm. Forearm blood flow (FBF) was measured by venous occlusion plethysmography. All groups responded with a decrease in whole body insulin sensitivity in response to bedrest [CON group: 6.8 +/- 0.5 to 4.3 +/- 0.3 mg x min(-1) x kg(-1) (P < 0.0001), LBW group: 6.2 +/- 0.5 to 4.3 +/- 0.3 mg x min(-1) x kg(-1) (P < 0.0001), and FDR group: 4.3 +/- 0.7 to 3.1 +/- 0.3 mg x min(-1) x kg(-1) (P = 0.068)]. The percent decrease was significantly greater in the CON group compared with the FDR group (CON group: 34 +/- 4%, LBW group: 27 +/- 4%, and FDR group: 10 +/- 13%). Forearm insulin-stimulated glucose clearance decreased significantly in the CON and LBW groups in response to bedrest;...Continue Reading

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Citations

Oct 14, 2011·The Journal of Clinical Endocrinology and Metabolism·Sylvie Dufour, Kitt Falk Petersen
Jul 24, 2014·Current Diabetes Reports·Paddy C DempseyDavid W Dunstan
Mar 10, 2012·Diabetes·Rasmus S BiensøJørgen F P Wojtaszewski
Apr 24, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Abeer M MahmoudJacob M Haus
Oct 22, 2016·Clinical Hemorheology and Microcirculation·Helena Lenasi, Markos Klonizakis
Mar 17, 2018·The Journal of Clinical Endocrinology and Metabolism·Floriane RudwillAudrey Bergouignan
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Apr 27, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·John P Thyfault, Frank W Booth
Aug 13, 2011·Journal of Applied Physiology·Audrey BergouignanStéphane Blanc
Jul 20, 2012·Medicine and Science in Sports and Exercise·Katherine L SchofieldHamish Osborne
Jul 15, 2017·Journal of Applied Physiology·Mathias Ried-LarsenMichael J Joyner
Nov 10, 2011·American Journal of Physiology. Endocrinology and Metabolism·Richard A M JonkersJeanine Josephine Prompers
Jul 29, 2019·Enfermería clínica·Lina ErlinaDewi Gayatri
Sep 5, 2021·The Journal of Clinical Endocrinology and Metabolism·William V TrimDylan Thompson

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