Effect of 12-month nasal continuous positive airway pressure therapy for obstructive sleep apnea on progression of chronic kidney disease

Medicine
Xiaoming LiMin Han

Abstract

Obstructive sleep apnea (OSA) is common among patients with chronic kidney disease (CKD). CKD may increase the risk of OSA, and OSA may increase the risk of renal injury. Nasal continuous positive airway pressure (nCPAP) is the standard treatment for OSA. However, the effect of nCPAP on the progression of CKD is unclear. A total of 395 patients with stage 3/4 CKD were initially examined, and 269 patients (148 non-OSA cases; 79 mild OSA cases; 42 moderate/severe OSA cases) were analyzed after implementation of the exclusion criteria. The severity of OSA was determined by polysomnography (PSG). Fifty-two OSA patients (32 mild OSA cases; 20 moderate/severe OSA cases) received nCPAP treatment for 12 months. Variables associated with OSA severity and estimated glomerular filtration rate (eGFR) were evaluated before and after the 12-month nCPAP treatment. Among all 269 CKD patients, body mass index (BMI), and eGFR had significant associations with OSA severity. Age, BMI, apnea-hypopnea index (AHI), mean SaO2%, and SaO2 <90% monitoring time had independent associations with lower eGFR. The 12-month nCPAP treatment significantly reduced the rate of eGFR decline. Univariate and multivariate analysis indicated that age, BMI, AHI, mean Sa...Continue Reading

References

Jun 10, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R L BenzD D Peterson
Dec 6, 2002·Journal of the American Society of Nephrology : JASN·Carmine ZoccaliPietro Finocchiaro
Mar 27, 2004·Seminars in Dialysis·Patrick Hanly
Feb 19, 2005·Advances in Chronic Kidney Disease·Kathryn J Wiggins, David W Johnson
Nov 18, 2005·Journal of the American Society of Nephrology : JASN·Masaomi Nangaku
Apr 7, 2006·Lung·Nikolaos MarkouStavros Konstantopoulos
Aug 14, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Georg FleischmannPeter Kotanko
Aug 3, 2010·Current Hypertension Reports·Gbemisola A Adeseun, Sylvia E Rosas
Jan 12, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Takahiro MasudaYasushi Asano
Mar 19, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Yusuke SakaguchiYoshiharu Tsubakihara
Mar 29, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Maria-Eleni RoumeliotiMark L Unruh
May 12, 2011·PloS One·Sofia B AhmedPatrick J Hanly
Mar 6, 2012·Journal of Hypertension·Khaled Abdel-KaderMark L Unruh
Jan 22, 2014·Journal of Nephrology·Ana María Gámez-MéndezBruno Escalante
Mar 14, 2014·American Journal of Hypertension·Dominik LinzMichael Böhm
Jul 17, 2014·Sleep & Breathing = Schlaf & Atmung·Zehra Aşuk YaşarGültekin Tibet
Apr 8, 2015·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Bisher AbuyassinIsmail Laher
Jun 24, 2015·American Journal of Respiratory and Critical Care Medicine·Ann A ZaluckySofia B Ahmed

❮ Previous
Next ❯

Citations

Mar 18, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Urmi ShethSirimon Reutrakul
Jul 28, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Urmi ShethSirimon Reutrakul

❮ Previous
Next ❯

Software Mentioned

AirView
SPSS

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.