Effect of 12-week vanadate and magnesium co-administration on chosen haematological parameters as well as on some indices of iron and copper metabolism and biomarkers of oxidative stress in rats

Environmental Toxicology and Pharmacology
Agnieszka ScibiorIrmina Niedźwiecka

Abstract

Changes in some blood parameters after 12-week administration of sodium metavanadate (SMV; 0.125mgV/ml) or/and magnesium sulphate (MS; 0.06mgMg/ml) in drinking water were studied in outbred male Wistar rats (16 rats/each group) to explore the probable mechanism(s) underlying SMV toxicity and check whether Mg at the level selected during SMV co-administration can protect, at least in part, from a possible deleterious action of SMV. Exposure to SMV alone and in combination with MS (a) led to a decrease in fluid and food intake and body weight gain; (b) predisposed the animals to the development of microcytic-hypochromic anaemia (with excessive liver and spleen Fe deposition, unaltered plasma Fe level and enhanced Zn concentration in the erythrocytes (RBCs) characterized by a reduced haematocrit (Ht) index and haemoglobin (Hb) level, unchanged erythrocyte and reticulocyte count, anisocytosis, lowered total iron binding capacity (TIBC) and elevated transferrin saturation (TS); (c) disturbed Cu homeostasis, but (d) did not influence the leukocyte count and the plasma total antioxidant status (TAS). We suggest that abnormal metabolism and accumulation of Fe as well as an altered Cu status and the RBC Zn level might lead to defective ...Continue Reading

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Citations

Jun 15, 2013·Oxidative Medicine and Cellular Longevity·Agnieszka ScibiorIrmina Niedźwiecka
Jul 24, 2015·Bulletin of Environmental Contamination and Toxicology·Iwona Zwolak
Aug 30, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Cristina Sánchez-GonzálezJuan Llopis
Dec 23, 2014·Environmental Toxicology and Pharmacology·Samuel Jerry CobbinaLiuqing Yang
Jan 10, 2019·Current Medicinal Chemistry·Agnieszka Ścibior, Joanna Kurus
Apr 20, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Agnieszka ŚcibiorAndrzej Skiba

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