PMID: 3773531Oct 1, 1986Paper

Effect of 1,4,6-androstatriene-3,17-dione (ATD), 4-hydroxy-4-androstene-3,17-dione (4-OH-A) and 4-acetoxy-4-androstene-3,17-dione (4-Ac-A) on the 5 alpha-reduction of androgens in the rat prostate

Journal of Steroid Biochemistry
M MottaL Martini

Abstract

The present study reports the effects exerted by 1,4,6-androstatriene-3,17-dione (ATD), 4-hydroxy-4-androstene-3,17-dione (4-OH-A) and 4-acetoxy-4-androstene-3,17-dione (4-Ac-A), three steroids known to inhibit the aromatization of androgens to estrogens, on the in vitro metabolism of labelled testosterone (T), dihydrotestosterone (DHT) and androstenedione (delta-4-A) in the ventral prostate of adult male rats. It has been found that ATD, in the concentration tested, does not influence the conversion of labelled T into DHT, but decreases the formation of 5 alpha-androstane-3 alpha,17 beta-diol and 5 alpha-androstane-3 beta,17 beta-diol (diols). On the contrary, 4-OH-A and 4-Ac-A simultaneously decrease the formation of DHT and the diols. When T is used as the substrate, the presence in the medium of these three steroids enhances the formation of delta-4-A and of 5 alpha-androstanedione (5 alpha-A). ATD, but not 4-OH-A and 4-Ac-A inhibits the conversion of labelled DHT into the diols. The transformation of labelled delta-4-A into 5 alpha-A is not modified by either ATD or 4-OH-A, while 4-Ac-A exerts only a small inhibition. These results suggest that the three aromatase inhibitors tested are able to profoundly modify the metabol...Continue Reading

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Citations

Jan 1, 1986·Journal of Steroid Biochemistry·A M BrodieR C Coombes
Nov 1, 1986·Journal of Steroid Biochemistry·M MottaL Martini
Jun 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·S ZoppiM Motta
Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·L MartiniR Maggi
Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·R C MelcangiL Martini
Oct 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·P Negri-Cesi, M Motta
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·P LimontaM Motta
Oct 9, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carlos A A PenattiLeslie P Henderson
Feb 16, 2006·Molecular and Cellular Endocrinology·Bernard Robaire, Natali A Henderson
Dec 18, 2008·Rapid Communications in Mass Spectrometry : RCM·Maria K ParrWilhelm Schänzer
Apr 1, 2003·Journal of Applied Physiology·Christian P SchneiderIrshad H Chaudry
Jan 1, 1990·The Journal of International Medical Research·A V BonoP Preti
Jan 28, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ángeles Carrasco-RuizFrancisco Castelán
Oct 1, 1988·Journal of Steroid Biochemistry·S ZoppiM Motta

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