Effect of 17-beta-estradiol on dopamine, serotonine and GABA striatal levels in 6-hydroxydopamine-treated rats

Toxicology
Virginia PeinadoMaría Luisa Leret

Abstract

Intrastriatal injection (16microg) of the neurotoxic dopaminergic agent 6-hydroxydopamine (6-OHDA) in ovariectomized rats caused important reductions in striatal dopamine (DA) and serotonin (5-HT) levels and an increase in GABA content. Treatment of ovariectomized rats with estradiol (5 mg 17-beta-estradiol administered by a subcutaneous cannula) before 6-OHDA injection maintained the control levels of these neurotransmitters. The administration of estradiol after 6-OHDA injection did not lead to their recovery. These findings suggest that estradiol acts as a neuroprotectant--but not as a neuroreparatory agent--and that it might be able to attenuate striatal dopaminergic neuron degeneration caused by neurotoxic agents.

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Citations

Mar 6, 2007·Pharmacology & Therapeutics·Laszlo Prokai, James W Simpkins
Jun 19, 2010·CNS Neuroscience & Therapeutics·Maria Gabriela SánchezThérèse Di Paolo
May 15, 2015·European Archives of Psychiatry and Clinical Neuroscience·Riccardo Maria MartoniJoseph O'Neill

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