PMID: 15374094Sep 18, 2004Paper

Effect of 17beta estradiol and progesterone on the conformation of the chromatin of the liver of female Japanese quail during aging

Archives of Gerontology and Geriatrics
G MahendraM S Kanungo

Abstract

Plasma levels of 17beta estradiol and progesterone were measured by radioimmunoassay in immature, adult and old female Japanese quails. The levels of progesterone and the progesterone/estradiol ratio were maximum in adult, egg laying birds. Conformation of the chromatin of the liver of birds of various ages before and after administration of steroid hormones was studied by digesting the nuclei with micrococcal nuclease (MNase) and pancreatic deoxyribonuclease I (DNase I) followed by electrophoretic resolution of the DNA fragments. The pattern of bands shows that the chromatin of the adult is more sensitive to DNase I and MNase than that of young and old birds. Administration of 17beta estradiol and progesterone enhances the digestion of the chromatin by DNase I and MNase in old birds. Such enhancement does not occur in adult birds as the chromatin is already in relaxed and open conformation due to the high levels of the hormones already present at this age.

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Citations

Sep 18, 2004·Archives of Gerontology and Geriatrics·G Mahendra, M S Kanungo
Oct 29, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Maarten DhaenensDieter Deforce
Jan 11, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Alberto S MoraesMaria Luiza S Mello

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